SUSCEPTIBILITY TO RIFT VALLEY FEVER INFECTION AND ASSOCIATED RETINITIS

容易感染裂谷热和相关视网膜炎

• 批准号: 8171725
• 负责人: Catherine Marie Stein
• 金额: $ 0.49万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171725
• 关键词: Africa South of the Sahara; Bunyaviridae; Categories; Computer Retrieval of Information on Scientific Projects Database; Development; Epidemic; Family; Funding; Genetic; Genus Phlebovirus; Grant; Human; Individual; Infection; Institution; Livestock; Middle East; Pathogenesis; Predisposition; RNA Viruses; Research; Research Personnel; Resources; Retinitis; Rift Valley Fever; Rift Valley fever virus; Source; United States National Institutes of Health; adaptive immunity; epizootic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rift Valley fever virus (RVFV), a Category A negative stranded RNA virus (genus Phlebovirus, family Bunyaviridae), causes devastating livestock epizootics and concurrent human epidemics in sub-Saharan Africa and the Middle East. This project aims to examine genetic influences on the innate and adaptive immunity associated with RFVF pathogenesis, and genetic influences on the development of retinitis in RFVF-infected individuals.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 裂谷热病毒（RVFV）是一种A类负链RNA病毒（布尼亚病毒科，白蛉病毒属），在撒哈拉以南非洲和中东引起毁灭性的牲畜流行病和并发的人类流行病。 本项目旨在研究RFVF发病机制相关的先天性和适应性免疫的遗传影响，以及RFVF感染个体视网膜炎发展的遗传影响。