Genetics of TB resistance in HIV positive subjects
HIV 阳性受试者的结核病耐药性遗传学
基本信息
- 批准号:9511030
- 负责人:
- 金额:$ 58.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-01 至 2019-07-31
- 项目状态:已结题
- 来源:
- 关键词:5q31ATAC-seqAffectAfricaAfrica South of the SaharaAfricanAreaBacillus (bacterium)BacteriaBiologicalBiological AssayBotswanaCD4 Lymphocyte CountCandidate Disease GeneCause of DeathChromatinClinicalComplexControl GroupsCountryDNADNA MethylationDataDendritic CellsDevelopmentDiseaseEpigenetic ProcessExhibitsFunctional disorderGenesGeneticGenetic VariationGenetsGenomicsGenotypeGoalsHIVHIV SeropositivityHIV riskHela CellsHigh-Throughput Nucleotide SequencingHistonesHumanHuman GeneticsIL12B geneImmune responseImmunocompetentImmunocompromised HostImmunologicsIncidenceIndividualInfectionIntegration Host FactorsInterleukin-12InterventionKnowledgeLogistic RegressionsMapsMediatingMethylationMycobacterium tuberculosisPathway interactionsPatientsPatternPhenotypePopulationPredispositionProspective cohortQuantitative Trait LociRecruitment ActivityRegimenResearchResearch DesignResistanceRiskRoleSamplingTanzaniaTechnologyTestingTimeTransposaseTuberculin TestTuberculosisUgandaVaccine DesignVariantVirulentXCL1 genebasebead chipcase controlcohortcytokinedeep sequencingdensitydisorder riskepigenetic variationepigenomicsexperimental studygenetic variantgenome wide association studyinnovationinsightinterestmacrophagemethylomemonocytenovelpreventpromoterprospectiveresponserisk variantwhole genome
项目摘要
PROJECT SUMMARY
Tuberculosis (TB) is a re-emerging disease that is highly prevalent in the developing world,
especially sub-Saharan Africa. However, despite the fact that a third of humans are exposed to
Myocbacterium tuberculosis (MTB) complex bacteria, most immunocompetent individuals do not
progress to active TB, but remain with asymptomatic latent TB infections (LTBI). In contrast, in
immunocompromised individuals with LTBI, such as those infected with the human
immunodeficiency virus (HIV+), the risk of active disease is 10% and more per year, making TB
the most common cause of death for HIV+ individuals living in TB endemic countries.
Nonetheless, many HIV+ individuals do not progress to active disease, exhibiting a resistance
phenotype. We hypothesize that HIV+ individuals exposed to MTB, but who remain disease free
for several years carry genomic and/or epigenomic variants that strongly protect them from
active TB. To test this we will assay patterns of genetic and epigenetic variation in two
prospective African cohorts, Kampala, Uganda and Dar es Salaam, Tanzania, where HIV+
patients have been followed for over a decade. We will compare the distribution of variants in
people with active TB to those who have been exposed but do not develop disease. A third
cohort from the high incidence HIV regions of Botswana will also be studied using the same
platforms, high density GWAS and methylome chips, and ATAC-sequencing, to assess
association with TB. We will use identify candidate genes for deep re-sequencing in selected
individuals with the intent of identifying functional variants. Pathways that are found to protect
from active disease in highly susceptible HIV+ individuals should provide novel targets for both
treatment and means to prevent disease. Lastly, we will conduct immunological experiments to
examine how these genetic variants affect the immune response to TB. The knowledge gained
from this study design will be important in creating TB control regimens not only in Africa, but
worldwide, as it will elucidate targets of unusually large effect that have not been investigated so
far.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Catherine Marie Stein其他文献
Catherine Marie Stein的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Catherine Marie Stein', 18)}}的其他基金
Systems Biology, Bioinformatics, & Data Integration
系统生物学、生物信息学、
- 批准号:
10459538 - 财政年份:2021
- 资助金额:
$ 58.77万 - 项目类别:
Systems Biology, Bioinformatics, & Data Integration
系统生物学、生物信息学、
- 批准号:
10653908 - 财政年份:2021
- 资助金额:
$ 58.77万 - 项目类别:
Systems Biology, Bioinformatics, & Data Integration
系统生物学、生物信息学、
- 批准号:
10271171 - 财政年份:2021
- 资助金额:
$ 58.77万 - 项目类别:
SUSCEPTIBILITY TO RIFT VALLEY FEVER INFECTION AND ASSOCIATED RETINITIS
容易感染裂谷热和相关视网膜炎
- 批准号:
8171725 - 财政年份:2010
- 资助金额:
$ 58.77万 - 项目类别:
相似国自然基金
基于ATAC-seq与DNA甲基化测序探究染色质可及性对莲两生态型地下茎适应性分化的作用机制
- 批准号:
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
利用ATAC-seq联合RNA-seq分析TOP2A介导的HCC肿瘤细胞迁移侵
袭的机制研究
- 批准号:
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
面向图神经网络ATAC-seq模体识别的最小间隔单细胞聚类研究
- 批准号:62302218
- 批准年份:2023
- 资助金额:30.00 万元
- 项目类别:青年科学基金项目
基于ATAC-seq策略挖掘穿心莲基因组中调控穿心莲内酯合成的增强子
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
基于单细胞ATAC-seq技术的C4光合调控分子机制研究
- 批准号:
- 批准年份:2021
- 资助金额:30 万元
- 项目类别:青年科学基金项目
基于ATAC-seq技术研究交叉反应物质197调控TFEB介导的自噬抑制子宫内膜异位症侵袭的分子机制
- 批准号:82001520
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
靶向治疗动态调控肺癌细胞DNA可接近性的ATAC-seq分析
- 批准号:81802809
- 批准年份:2018
- 资助金额:21.0 万元
- 项目类别:青年科学基金项目
运用ATAC-seq技术分析染色质可接近性对犏牛初级精母细胞基因表达的调控作用
- 批准号:31802046
- 批准年份:2018
- 资助金额:27.0 万元
- 项目类别:青年科学基金项目
基于ATAC-seq和RNA-seq研究CWIN调控采后番茄果实耐冷性作用机制
- 批准号:31801915
- 批准年份:2018
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
基于ATAC-seq高精度预测染色质相互作用的新方法和基于增强现实的3D基因组数据可视化
- 批准号:31871331
- 批准年份:2018
- 资助金额:59.0 万元
- 项目类别:面上项目
相似海外基金
Project #2 Integrated single-nucleus multi-omics (ATAC-seq+RNA-seq or chromatin accessibility + RNA-seq) of human TGs
项目
- 批准号:
10806548 - 财政年份:2023
- 资助金额:
$ 58.77万 - 项目类别:
A transposase system for integrative ChIP-exo and ATAC-seq analysis at single-cell resolution
用于单细胞分辨率综合 ChIP-exo 和 ATAC-seq 分析的转座酶系统
- 批准号:
10210424 - 财政年份:2018
- 资助金额:
$ 58.77万 - 项目类别:
EAPSI: Developing Single Nucleus ATAC-seq to Map the Ageing Epigenome
EAPSI:开发单核 ATAC-seq 来绘制衰老表观基因组图谱
- 批准号:
1714070 - 财政年份:2017
- 资助金额:
$ 58.77万 - 项目类别:
Fellowship Award
A cloud-based learning module to analyze ATAC-seq and single cell ATAC-seq data
基于云的学习模块,用于分析 ATAC-seq 和单细胞 ATAC-seq 数据
- 批准号:
10558379 - 财政年份:2001
- 资助金额:
$ 58.77万 - 项目类别:














{{item.name}}会员




