ORAL MUCOSAL IMMUNITY IN VULNERABLE HIV INFECTED POPULATIONS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 自20世纪80年代首次描述感染以来，HIV/AIDS的口腔并发症（包括口腔念珠菌病、卡波西肉瘤、阿弗他溃疡、口腔毛状白斑、CMV、HSV、坏死性溃疡性牙周炎和口腔疣）的频率发生了变化。 人β防御素通过提供直接的抗微生物活性和通过介导与适应性免疫系统细胞的相互作用在粘膜防御中发挥核心作用。该项目旨在通过使用蛋白质组学，基因组学和蛋白质结构/功能方法确定HIV感染后口腔并发症的易感性，并专注于口腔粘膜和人类β防御素的先天免疫。 遗传分析将集中在先天免疫基因和艾滋病毒感染者口腔并发症的易感性之间的关联，以及β防御素基因的拷贝数变异和CCR 5与CXCR 4共同受体在艾滋病毒细胞进入中的易感性之间的关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The frequency of oral complications of HIV/AIDS; including oral candidiasis, Kaposi's sarcoma, aphthous ulcers, oral hairy leukoplakia, CMV, HSV, necrotizing ulcerative periodontitis, and oral warts have changed since the initial description of the infection in the 1980s. Human beta defensins play a central role in mucosal defenses by providing direct anti-microbial activity and by mediating cross-talk with cells of the adaptive immune system. This project aims to determine susceptibility to oral complications following HIV infection, by using proteomics, genomics, and protein structure/function approaches and to focus on innate immunity in the oral mucosa and human beta defensins. Genetic analyses will focus on the association between innate immunity genes and susceptibility to development of oral complications in HIV-infected individuals, and the association between copy number variants in beta defensin genes and susceptibility to CCR5 vs. CXCR4 co-receptor use in cellular entry of HIV.