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DESIGN OF LINKAGE STUDIES

DESIGN OF LINKAGE STUDIES
连锁研究的设计
批准号:
8171735
负责人:
Robert C. Elston
金额:
$0.49万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-08-01 至 2011-07-31

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项目成果

Robert C. Elston的其他基金

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESPAIR (DESign for PAIRs) is a computer program useful for designing a two-stage linkage study using relative pairs for a dichotomous phenotype. It determines the optimal two-stage study design - i.e., for specified power and significance level, how many pairs of relatives should be studied, how many equally spaced markers should be used initially, and what criterion should be used to specify the markers around which further searching should be done at a second stage. The program will calculate either the number of relative pairs required for a given number of first-stage markers or the number of markers required for a given number of relative pairs. We highlight the use of the latest version of DESPAIR to decide to what extent additional fine mapping in a candidate region of interest can lead to an increase in power in a previous linkage study sample. We also discuss new features of the program, such as the mean difference test for affected and discordant relative pairs and estimation of full sibling pair equivalents to design a study when several types of relative pairs are available. DESPAIR is part of the S.A.G.E. program package and is freely available for use online.
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HUMAN GENETIC ANALYSIS RESOURCE
  • 批准号:
    8364163
  • 项目类别:
  • 资助金额:
    $13.09万
  • 财政年份:
    2011
  • 负责人:
    Robert C. Elston
  • 依托单位:
TRAINING IN GENETIC EPIDEMIOLOGY & USE OF SAGE
  • 批准号:
    8171713
  • 项目类别:
  • 资助金额:
    $9.88万
  • 财政年份:
    2010
  • 负责人:
    Robert C. Elston
  • 依托单位:
STUDIES IN CARDIOVASCULAR DISEASE
  • 批准号:
    8171734
  • 项目类别:
  • 资助金额:
    $0.49万
  • 财政年份:
    2010
  • 负责人:
    Robert C. Elston
  • 依托单位:
GENOTYPE AND COPY NUMBER CALLING
  • 批准号:
    8171736
  • 项目类别:
  • 资助金额:
    $0.49万
  • 财政年份:
    2010
  • 负责人:
    Robert C. Elston
  • 依托单位: