DESIGN OF LINKAGE STUDIES
连锁研究的设计
基本信息
- 批准号:8171735
- 负责人:
- 金额:$ 0.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-08-01 至 2011-07-31
- 项目状态:已结题
- 来源:
- 关键词:AffectComputer Retrieval of Information on Scientific Projects DatabaseFundingGrantInstitutionLeadMapsPhenotypeRelative (related person)ResearchResearch DesignResearch PersonnelResourcesSampling StudiesSiblingsSourceSpecific qualifier valueStagingTestingTo specifyUnited States National Institutes of Healthcomputer programdesigninterestprograms
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
DESPAIR (DESign for PAIRs) is a computer program useful for designing a two-stage linkage study using relative pairs for a dichotomous phenotype. It determines the optimal two-stage study design - i.e., for specified power and significance level, how many pairs of relatives should be studied, how many equally spaced markers should be used initially, and what criterion should be used to specify the markers around which further searching should be done at a second stage. The program will calculate either the number of relative pairs required for a given number of first-stage markers or the number of markers required for a given number of relative pairs. We highlight the use of the latest version of DESPAIR to decide to what extent additional fine mapping in a candidate region of interest can lead to an increase in power in a previous linkage study sample. We also discuss new features of the program, such as the mean difference test for affected and discordant relative pairs and estimation of full sibling pair equivalents to design a study when several types of relative pairs are available. DESPAIR is part of the S.A.G.E. program package and is freely available for use online.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert C. Elston其他文献
Aerosol bronchodilator delivery methods. Relative impact on pulmonary function and cost of respiratory care.
气雾剂支气管扩张剂输送方法。
- DOI:
- 发表时间:
1989 - 期刊:
- 影响因子:0
- 作者:
Warren R. Summer;Robert C. Elston;Linda Tharpe;Steve Nelson;E. Haponik - 通讯作者:
E. Haponik
AUGMENTATION OF THE ANTIBODY RESPONSE BY HAPTEN HELP
HAPTEN HELP 增强抗体反应
- DOI:
- 发表时间:
1985 - 期刊:
- 影响因子:0
- 作者:
Stephen H. Leech;Christopher F. Bryan;Robert C. Elston - 通讯作者:
Robert C. Elston
A non-parametric method finds genetic etiology of nicotine dependence differs in males and females
- DOI:
10.1016/j.drugalcdep.2015.07.372 - 发表时间:
2015-11-01 - 期刊:
- 影响因子:
- 作者:
Qing Lu;Changshuai Wei;Robert C. Elston;Olga Vsevolozhskaya - 通讯作者:
Olga Vsevolozhskaya
Measures of observer agreement when binomial data are collected in free operant situations
- DOI:
10.1007/bf01341225 - 发表时间:
1982-12-01 - 期刊:
- 影响因子:1.700
- 作者:
Robert C. Elston;Stephen R. Schroeder;Johannes Rojahn - 通讯作者:
Johannes Rojahn
Genetic analysis of von Willebrand's disease in two large pedigrees: a multivariate approach.
两个大家系中冯维勒布兰德病的遗传分析:多变量方法。
- DOI:
- 发表时间:
1980 - 期刊:
- 影响因子:0
- 作者:
Lynn R. Goldin;Robert C. Elston;J. B. Graham;Connie H. Miller;Edmond A. Murphy - 通讯作者:
Edmond A. Murphy
Robert C. Elston的其他文献
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{{ truncateString('Robert C. Elston', 18)}}的其他基金
SERVICE TO GENETIC EPIDEMIOLOGISTS AND USERS OF SAGE
为遗传流行病学家和 SAGE 用户提供服务
- 批准号:
8171714 - 财政年份:2010
- 资助金额:
$ 0.49万 - 项目类别:
DEVELOPMENT OF PORTABLE COMPUTER PROGRAMS FOR HUMAN GENETIC ANALYSIS
用于人类遗传分析的便携式计算机程序的开发
- 批准号:
8171710 - 财政年份:2010
- 资助金额:
$ 0.49万 - 项目类别:














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