STUDIES IN ALZHEIMER'S DISEASE
STUDIES IN ALZHEIMER'S DISEASE
批准号:
8171733
负责人:
Robert C. Elston
金额:
$0.49万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-08-01 至 2011-07-31
关键词:
AfricanAfrican AmericanAlzheimer&aposs DiseaseApolipoprotein ECognitiveCommunitiesComputer Retrieval of Information on Scientific Projects DatabaseDementiaDiseaseEducationElderlyFundingGene FrequencyGrantInstitutionInterviewKenyaLanguageMethodsNigeriaResearchResearch PersonnelResourcesSamplingScreening procedureSensitivity and SpecificitySourceSusceptibility GeneTranslatingUnited States National Institutes of Healthage relatedinformantvascular factor
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E epsilon 4 allele frequencies were high (approximately 30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.
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会议论文
HUMAN GENETIC ANALYSIS RESOURCE
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批准号:8364163
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项目类别:
-
资助金额:$13.09万
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财政年份:2011
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负责人:Robert C. Elston
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依托单位:
TRAINING IN GENETIC EPIDEMIOLOGY & USE OF SAGE
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批准号:8171713
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项目类别:
-
资助金额:$9.88万
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财政年份:2010
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负责人:Robert C. Elston
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依托单位:
STUDIES IN CARDIOVASCULAR DISEASE
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批准号:8171734
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项目类别:
-
资助金额:$0.49万
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财政年份:2010
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负责人:Robert C. Elston
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依托单位:
DESIGN OF LINKAGE STUDIES
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批准号:8171735
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项目类别:
-
资助金额:$0.49万
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财政年份:2010
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负责人:Robert C. Elston
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依托单位:
GENOTYPE AND COPY NUMBER CALLING
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批准号:8171736
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项目类别:
-
资助金额:$0.49万
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财政年份:2010
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负责人:Robert C. Elston
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依托单位:
SERVICE TO GENETIC EPIDEMIOLOGISTS AND USERS OF SAGE
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批准号:8171714
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项目类别:
-
资助金额:$8.9万
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财政年份:2010
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负责人:Robert C. Elston
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依托单位:
GENETIC ANALYSIS WORKSHOP 16
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批准号:8171715
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项目类别:
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资助金额:$3.95万
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财政年份:2010
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负责人:Robert C. Elston
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依托单位:
DEVELOPMENT OF PORTABLE COMPUTER PROGRAMS FOR HUMAN GENETIC ANALYSIS
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批准号:8171710
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项目类别:
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资助金额:$50.41万
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财政年份:2010
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负责人:Robert C. Elston
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依托单位:
TRAINING IN GENETIC EPIDEMIOLOGY & USE OF SAGE
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批准号:7956478
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项目类别:
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资助金额:$9.7万
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财政年份:2009
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负责人:Robert C. Elston
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依托单位:
Human Genetic Analysis Resource
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批准号:7897983
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项目类别:
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资助金额:$92.26万
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财政年份:2009
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负责人:Robert C. Elston
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依托单位:
SERVICE TO GENETIC EPIDEMIOLOGISTS AND USERS OF SAGE
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批准号:7956479
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项目类别:
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资助金额:$8.73万
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财政年份:2009
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负责人:Robert C. Elston
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依托单位:
DEVELOPMENT OF PORTABLE COMPUTER PROGRAMS FOR HUMAN GENETIC ANALYSIS
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批准号:7956475
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项目类别:
-
资助金额:$49.45万
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财政年份:2009
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负责人:Robert C. Elston
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依托单位:
GENETIC ANALYSIS WORKSHOP 16
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批准号:7956480
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项目类别:
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资助金额:$3.88万
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财政年份:2009
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负责人:Robert C. Elston
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依托单位:
STUDIES OF OBSTRUCTIVE SLEEP APNEA
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批准号:7723437
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项目类别:
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资助金额:$1.82万
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财政年份:2008
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负责人:Robert C. Elston
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依托单位:
DEVELOPMENT OF PORTABLE COMPUTER PROGRAMS FOR HUMAN GENETIC ANALYSIS
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批准号:7723433
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项目类别:
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资助金额:$46.37万
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财政年份:2008
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负责人:Robert C. Elston
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依托单位:
STUDIES IN COLORECTAL AND RELATED CANCERS
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批准号:7723455
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项目类别:
-
资助金额:$1.82万
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财政年份:2008
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负责人:Robert C. Elston
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依托单位:
GENETIC ANALYSIS WORKSHOP 15
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批准号:7723441
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项目类别:
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资助金额:$3.64万
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财政年份:2008
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负责人:Robert C. Elston
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依托单位:
MULTISTAGE SAMPLING FOR GENETIC STUDIES
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批准号:7723449
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项目类别:
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资助金额:$0.45万
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财政年份:2008
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负责人:Robert C. Elston
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依托单位:
SERVICE TO GENETIC EPIDEMIOLOGISTS AND USERS OF SAGE
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批准号:7723439
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项目类别:
-
资助金额:$8.18万
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财政年份:2008
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负责人:Robert C. Elston
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依托单位:
TRAINING IN GENETIC EPIDEMIOLOGY & USE OF SAGE
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批准号:7723438
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项目类别:
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资助金额:$9.09万
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财政年份:2008
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负责人:Robert C. Elston
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依托单位:
海外基金