STUDIES IN ALZHEIMER'S DISEASE

阿尔茨海默病的研究

• 批准号: 8171733
• 负责人: Robert C. Elston
• 金额: $ 0.49万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171733
• 关键词: African; African American; Alzheimer' s Disease; Apolipoprotein E; Cognitive; Communities; Computer Retrieval of Information on Scientific Projects Database; Dementia; Disease; Education; Elderly; Funding; Gene Frequency; Grant; Institution; Interview; Kenya; Language; Methods; Nigeria; Research; Research Personnel; Resources; Sampling; Screening procedure; Sensitivity and Specificity; Source; Susceptibility Gene; Translating; United States National Institutes of Health; age related; informant; vascular factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E epsilon 4 allele frequencies were high (approximately 30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 以前的研究已经建立了跨文化方法来筛查与衰老相关的痴呆症和易感基因，特别是在加拿大克里人、非裔美国人和尼日利亚约鲁巴人中患有阿尔茨海默病(AD)。我们确定了社区痴呆症筛查访谈(CSID)是否可以用来评估阿尔茨海默病类型的痴呆症。CSID翻译成肯尼亚的一种主要语言Kikuyu。使用认知得分和告密者得分的两组系数，计算了100名年长(65岁)尼耶里肯尼亚人每人的两个判别函数(DF)得分。当选择100%敏感性的分界点时，在肯尼亚样本中，DF评分的特异度非常相似(93.75%)。我们建议可以利用适应的CSID来检测东非人中的痴呆症。我们还发现载脂蛋白E epsilon 4等位基因频率很高(约30%)，并且在正常受试者和可能的AD患者之间没有差别。没有证据表明多年的教育或血管因素与痴呆症状态有关。