STUDIES IN ALZHEIMER'S DISEASE

阿尔茨海默病的研究

• 批准号: 8171733
• 负责人: Robert C. Elston
• 金额: $ 0.49万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171733
• 关键词: African; African American; Alzheimer' s Disease; Apolipoprotein E; Cognitive; Communities; Computer Retrieval of Information on Scientific Projects Database; Dementia; Disease; Education; Elderly; Funding; Gene Frequency; Grant; Institution; Interview; Kenya; Language; Methods; Nigeria; Research; Research Personnel; Resources; Sampling; Screening procedure; Sensitivity and Specificity; Source; Susceptibility Gene; Translating; United States National Institutes of Health; age related; informant; vascular factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E epsilon 4 allele frequencies were high (approximately 30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 先前的研究已经建立了跨文化方法来筛选与衰老相关的痴呆和易感基因，特别是在加拿大克里人、非洲裔美国人和尼日利亚的约鲁巴人中的阿尔茨海默病（AD）。我们确定是否社区筛查访谈痴呆症（CSID），翻译成基库尤，肯尼亚的主要语言，可以用来评估阿尔茨海默型痴呆症。使用两组认知和信息得分的系数，计算100名老年人（>65岁）Nyeri肯尼亚人的两个判别函数（DF）得分。当截止点选择为100%的敏感性，DF评分的特异性是非常相似的（93.75%），在肯尼亚样本。我们建议适应CSID可用于检测东非人中的痴呆症。我们还发现，载脂蛋白E β 4等位基因频率很高（约30%），正常人和可能患有AD的人之间没有差异。没有证据表明教育年限或血管因素与痴呆状态相关。