GENETIC ANALYSIS WORKSHOP 16

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 每两年举行一次遗传分析研讨会，国际知名的遗传流行病学家在会上分析真实的和模拟数据集，以展示遗传分析的新方法。 第16次全球大气观测的分析工作于2008年开始，有两个真实的数据集和一个模拟数据集。 第一个真实的数据集包括病例对照数据，包括2,062名参与者的近550,000个单核苷酸多态性（SNP）的表型和基因型，来自风湿性关节炎遗传学的多中心研究。 第二个真实的数据集包括来自Fractionary Heart研究的765个家系，包括来自9个检查期的数十种表型和总共6，752个分型个体的550，000个SNP的基因型。 模拟数据集由100个重复样本组成，这些样本基于第二个真实的数据集中包含的6，476名Fracket研究参与者。 表型，包括心肌梗死和血脂水平，模拟使用一个复杂的模型，将许多相互作用的遗传决定因素和环境因素，提供了丰富多样的分析可能性的遗传流行病学家。 该研讨会的论文现已出版。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Every two years a Genetic Analysis Workship (GAW) is held, at which internationally reputed genetic epidemiologists analyze real and simulated data sets in order to demonstrate new methods of genetic analysis. For the 16th GAW, for which analytical work was begun in 2008, two real and one simulated data set were available. The first real data set comprised case-control data, including phenotypes and genotypes for nearly 550,000 single-nucleotide polymorphisms (SNPs) on 2,062 participants, from a multicenter study of the genetics of rheumatoid arthritis. The second real data set comprised 765 pedigrees from the Framingham Heart Study, including dozens of phenotypes from nine examination period and genotypes for 550,000 SNPs on a total of 6,752 typed individuals. The simulated data set consisted of 100 replicate samples based on 6,476 of the Framingham study participants included in the second real data set. Phenotypes, including myocardial infarction and serum lipid levels, were simulated using a complex model incorporating many interacting genetic determinants and environmental factors, providing the genetic epidemiologist with a rich variety of analytical possibilities. Papers from this workshop are now published.