GENETIC ANALYSIS WORKSHOP 16

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 每两年举行一次遗传分析工作组(GAW)，国际知名的遗传流行病学家在会上分析真实和模拟的数据集，以演示新的遗传分析方法。关于2008年开始分析工作的第16次全球公认会计准则，提供了两套真实数据和一套模拟数据。第一个真实的数据集包括病例对照数据，包括2062名参与者的近550,000个单核苷酸多态(SNPs)的表型和基因类型，这些数据来自一项关于类风湿性关节炎遗传学的多中心研究。第二个真实的数据集包括弗雷明翰心脏研究的765个家系，包括来自9个检查时期的数十个表型和总计6752个分型个体的550,000个SNP的基因类型。模拟数据集由100个重复样本组成，这些样本来自第二个真实数据集中包括的6476名弗雷明翰研究参与者。表型，包括心肌梗死和血脂水平，使用包含许多相互作用的遗传决定因素和环境因素的复杂模型进行模拟，为遗传流行病学家提供了丰富的各种分析可能性。这次研讨会的论文现已发表。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Every two years a Genetic Analysis Workship (GAW) is held, at which internationally reputed genetic epidemiologists analyze real and simulated data sets in order to demonstrate new methods of genetic analysis. For the 16th GAW, for which analytical work was begun in 2008, two real and one simulated data set were available. The first real data set comprised case-control data, including phenotypes and genotypes for nearly 550,000 single-nucleotide polymorphisms (SNPs) on 2,062 participants, from a multicenter study of the genetics of rheumatoid arthritis. The second real data set comprised 765 pedigrees from the Framingham Heart Study, including dozens of phenotypes from nine examination period and genotypes for 550,000 SNPs on a total of 6,752 typed individuals. The simulated data set consisted of 100 replicate samples based on 6,476 of the Framingham study participants included in the second real data set. Phenotypes, including myocardial infarction and serum lipid levels, were simulated using a complex model incorporating many interacting genetic determinants and environmental factors, providing the genetic epidemiologist with a rich variety of analytical possibilities. Papers from this workshop are now published.