GENETIC ANALYSIS WORKSHOP 16
遗传分析研讨会 16
基本信息
- 批准号:8171715
- 负责人:
- 金额:$ 3.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-08-01 至 2011-07-31
- 项目状态:已结题
- 来源:
- 关键词:ComplexComputer Retrieval of Information on Scientific Projects DatabaseDataData SetEducational workshopEnvironmental Risk FactorEpidemiologistFramingham Heart StudyFundingGeneticGenetic DeterminismGenotypeGrantIndividualInstitutionLipidsMethodsModelingMulticenter StudiesMyocardial InfarctionPaperParticipantPhenotypePublishingResearchResearch PersonnelResourcesRheumatoid ArthritisSamplingSerumSimulateSingle Nucleotide PolymorphismSourceUnited States National Institutes of HealthWorkbasecase controlgenetic analysisgenetic pedigree
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Every two years a Genetic Analysis Workship (GAW) is held, at which internationally reputed genetic epidemiologists analyze real and simulated data sets in order to demonstrate new methods of genetic analysis. For the 16th GAW, for which analytical work was begun in 2008, two real and one simulated data set were available. The first real data set comprised case-control data, including phenotypes and genotypes for nearly 550,000 single-nucleotide polymorphisms (SNPs) on 2,062 participants, from a multicenter study of the genetics of rheumatoid arthritis. The second real data set comprised 765 pedigrees from the Framingham Heart Study, including dozens of phenotypes from nine examination period and genotypes for 550,000 SNPs on a total of 6,752 typed individuals. The simulated data set consisted of 100 replicate samples based on 6,476 of the Framingham study participants included in the second real data set. Phenotypes, including myocardial infarction and serum lipid levels, were simulated using a complex model incorporating many interacting genetic determinants and environmental factors, providing the genetic epidemiologist with a rich variety of analytical possibilities. Papers from this workshop are now published.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
每两年举行一次遗传分析研讨会,国际知名的遗传流行病学家在会上分析真实的和模拟数据集,以展示遗传分析的新方法。 第16次全球大气观测的分析工作于2008年开始,有两个真实的数据集和一个模拟数据集。 第一个真实的数据集包括病例对照数据,包括2,062名参与者的近550,000个单核苷酸多态性(SNP)的表型和基因型,来自风湿性关节炎遗传学的多中心研究。 第二个真实的数据集包括来自Fractionary Heart研究的765个家系,包括来自9个检查期的数十种表型和总共6,752个分型个体的550,000个SNP的基因型。 模拟数据集由100个重复样本组成,这些样本基于第二个真实的数据集中包含的6,476名Fracket研究参与者。 表型,包括心肌梗死和血脂水平,模拟使用一个复杂的模型,将许多相互作用的遗传决定因素和环境因素,提供了丰富多样的分析可能性的遗传流行病学家。 该研讨会的论文现已出版。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Robert C. Elston其他文献
Aerosol bronchodilator delivery methods. Relative impact on pulmonary function and cost of respiratory care.
气雾剂支气管扩张剂输送方法。
- DOI:
- 发表时间:
1989 - 期刊:
- 影响因子:0
- 作者:
Warren R. Summer;Robert C. Elston;Linda Tharpe;Steve Nelson;E. Haponik - 通讯作者:
E. Haponik
AUGMENTATION OF THE ANTIBODY RESPONSE BY HAPTEN HELP
HAPTEN HELP 增强抗体反应
- DOI:
- 发表时间:
1985 - 期刊:
- 影响因子:0
- 作者:
Stephen H. Leech;Christopher F. Bryan;Robert C. Elston - 通讯作者:
Robert C. Elston
A non-parametric method finds genetic etiology of nicotine dependence differs in males and females
- DOI:
10.1016/j.drugalcdep.2015.07.372 - 发表时间:
2015-11-01 - 期刊:
- 影响因子:
- 作者:
Qing Lu;Changshuai Wei;Robert C. Elston;Olga Vsevolozhskaya - 通讯作者:
Olga Vsevolozhskaya
Measures of observer agreement when binomial data are collected in free operant situations
- DOI:
10.1007/bf01341225 - 发表时间:
1982-12-01 - 期刊:
- 影响因子:1.700
- 作者:
Robert C. Elston;Stephen R. Schroeder;Johannes Rojahn - 通讯作者:
Johannes Rojahn
Genetic analysis of von Willebrand's disease in two large pedigrees: a multivariate approach.
两个大家系中冯维勒布兰德病的遗传分析:多变量方法。
- DOI:
- 发表时间:
1980 - 期刊:
- 影响因子:0
- 作者:
Lynn R. Goldin;Robert C. Elston;J. B. Graham;Connie H. Miller;Edmond A. Murphy - 通讯作者:
Edmond A. Murphy
Robert C. Elston的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Robert C. Elston', 18)}}的其他基金
SERVICE TO GENETIC EPIDEMIOLOGISTS AND USERS OF SAGE
为遗传流行病学家和 SAGE 用户提供服务
- 批准号:
8171714 - 财政年份:2010
- 资助金额:
$ 3.95万 - 项目类别:
DEVELOPMENT OF PORTABLE COMPUTER PROGRAMS FOR HUMAN GENETIC ANALYSIS
用于人类遗传分析的便携式计算机程序的开发
- 批准号:
8171710 - 财政年份:2010
- 资助金额:
$ 3.95万 - 项目类别: