STRUCTURE OF THE B SUBTILIS SEPTUM DURING DNA TRANSLOCATION

DNA 易位过程中枯草芽孢杆菌隔膜的结构

• 批准号: 8169638
• 负责人: Kit J Pogliano
• 金额: $ 4.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169638
• 关键词: Bacillus anthracis; Bacillus subtilis; Cells; Computer Retrieval of Information on Scientific Projects Database; Cytoplasm; Endospore-Forming Bacteria; Funding; Grant; Institution; Membrane; Mothers; Pathway interactions; Phagocytosis; Play; Process; Research; Research Personnel; Resolution; Resources; Role; Signal Transduction; Source; Structure; United States National Institutes of Health; migration; protein complex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The phagocytosis-like process of engulfment is a key step in the sporulation pathway of the endospore forming bacteria, such as Bacillus subtilis and B. anthracis. During engulfment, the membrane of one bacterial cell (the mother cell) migrates around another, until the second cell is fully enclosed within the mother cell cytoplasm. We propose using the NCMIR to provide a higher resolution view of key steps in engulfment, including the steps of membrane migration, membrane fission and the assembly of protein complexes that play a synapse-like role coordinating signal transduction in the two cells.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 吞噬类吞噬过程是枯草芽孢杆菌和炭疽芽孢杆菌等内孢子形成细菌孢子形成途径中的关键步骤。在吞噬过程中，一个细菌细胞(母细胞)的膜在另一个细菌细胞周围迁移，直到第二个细胞完全被包围在母细胞细胞质中。我们建议使用NCMIR提供吞噬过程中关键步骤的更高分辨率的图像，包括膜迁移、膜分裂和蛋白质复合体的组装，这些复合体在两个细胞中扮演着突触样的协调信号转导的角色。