STRUCTURE OF THE B SUBTILIS SEPTUM DURING DNA TRANSLOCATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 吞噬过程是芽孢形成菌（如枯草芽孢杆菌和B）孢子形成途径中的关键步骤。炭疽病在吞噬过程中，一个细菌细胞（母细胞）的膜围绕另一个细胞迁移，直到第二个细胞完全封闭在母细胞的细胞质中。我们建议使用NCMIR来提供更高分辨率的视图，包括膜迁移，膜分裂和蛋白质复合物组装的步骤，这些蛋白质复合物在两个细胞中发挥突触样作用，协调信号转导。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The phagocytosis-like process of engulfment is a key step in the sporulation pathway of the endospore forming bacteria, such as Bacillus subtilis and B. anthracis. During engulfment, the membrane of one bacterial cell (the mother cell) migrates around another, until the second cell is fully enclosed within the mother cell cytoplasm. We propose using the NCMIR to provide a higher resolution view of key steps in engulfment, including the steps of membrane migration, membrane fission and the assembly of protein complexes that play a synapse-like role coordinating signal transduction in the two cells.