FRIENDLY GRANT FOR INCOMING FACULTY MEMBER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 基因复制是基因家族和基因组结构进化的重要机制。确定基因复制的年龄对于理解现代基因组中进化事件和基因功能之间的关系是很重要的。一般来说，基因复制日期不能直接从序列中确定，因为突变率不是恒定的。然而，我们可以通过使用进化树校准相对于物种形成事件的复制来估计基因复制发生的时间。许多关于基因重复测年的研究已经出现在分子进化文献中。这些分析都是手工完成的。数据集正在大幅增长，以至于它们现在处于传统方法可以分析的极限，即使是现有的数据集也承认替代假设，如果没有自动化，这些假设将过于乏味而无法考虑。我的研究涉及自动分析基因复制事件历史的算法的设计和实现，为大规模基因组分析提供了基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gene duplication is a crucial mechanism in the evolution of gene families and genomic structure. Determining the age of gene duplications is important to understanding the relationship between evolutionary events and gene function i modern genomes. Gene duplication dates cannot, in general, be determined directly from sequence because mutation rates are not constant. We can, however, estimate when gene duplications took place by calibrating duplication with respect to speciation events using evolutionary trees. Many studies of gene duplication dating have appeared in the molecular evolution literature. These analyses have been performed by hand. Data sets are growing substantially, so that they are now at the limit of what can be analyzed by traditional methods, and even existing data sets admit alternative hypotheses which would be too tedious to consider without automation. My research involve the design and implementation of algorithms to analyze the history of gene duplication events automatically, providing a building block for large-scale genomic analysis.