ASSESSMENT OF BRAIN IRON AND NEURONAL INTEGRITY USING NOVEL T1? AND T2? MRI
使用 NOVEL T1 评估脑铁和神经元完整性?
基本信息
- 批准号:8170462
- 负责人:
- 金额:$ 1.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-06-01 至 2011-05-31
- 项目状态:已结题
- 来源:
- 关键词:BrainComputer Retrieval of Information on Scientific Projects DatabaseFundingGrantImaging TechniquesInjection of therapeutic agentInstitutionIronMagnetic Resonance ImagingMethodsNeuronsOxidopamineParkinson DiseasePathway interactionsResearchResearch PersonnelResolutionResourcesSourceSubstantia nigra structureTechniquesUnited States National Institutes of Healthaphakia micedensitydopaminergic neuronmouse modelneuron lossnoveltool
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
In this project we aim to establish novel high-resolution magnetic resonance imaging (MRI) technique, T1¿, as quantitative methods sensitive to neuronal loss in the brain. We will investigate the predictive/discriminatory ability of the T1¿ using a unilateral 6-hydroxydopamine (6-OHDA) PD mouse model (intrastriatal injection of 2 ¿g 6-OHDA/¿L). We will study the functional relationship between T1¿ with neuronal density in aphakia mice (where the deficit of dopaminergic neurons in substantia nigra and the pathways for survival of neurons are well investigated). Once validated, the technique proposed here can be used as a valuable tool to investigate if and how neuronal loss in substantia nigra is correlated with the progression of Parkinson's disease.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SHALOM MICHAELI其他文献
SHALOM MICHAELI的其他文献
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{{ truncateString('SHALOM MICHAELI', 18)}}的其他基金
Next-Generation fMRI with MB-SWIFT: Insights into the Origins of Contrast
采用 MB-SWIFT 的下一代功能磁共振成像:洞察对比度的起源
- 批准号:
10413244 - 财政年份:2021
- 资助金额:
$ 1.93万 - 项目类别:
Next-Generation fMRI with MB-SWIFT: Insights into the Origins of Contrast
采用 MB-SWIFT 的下一代功能磁共振成像:洞察对比度的起源
- 批准号:
10653089 - 财政年份:2021
- 资助金额:
$ 1.93万 - 项目类别:
Next-Generation fMRI with MB-SWIFT: Insights into the Origins of Contrast
采用 MB-SWIFT 的下一代功能磁共振成像:洞察对比度的起源
- 批准号:
10296096 - 财政年份:2021
- 资助金额:
$ 1.93万 - 项目类别:
NOVEL MRI METHODS IRON QUALIFICATION IN PARKINSON'S DISEASE
新型 MRI 方法 帕金森病中的铁含量
- 批准号:
8362890 - 财政年份:2011
- 资助金额:
$ 1.93万 - 项目类别:
ASSESSMENT OF BRIAN IRON & NEURONAL INTEGRITY USING NOVEL T1P & T2P MRI
布莱恩·艾恩的评估
- 批准号:
8362891 - 财政年份:2011
- 资助金额:
$ 1.93万 - 项目类别:
ASSESSMENT OF BRAIN IRON AND NEURONAL INTEGRITY USING NOVEL T1? AND T2? MRI
使用 NOVEL T1 评估脑铁和神经元完整性?
- 批准号:
8362857 - 财政年份:2011
- 资助金额:
$ 1.93万 - 项目类别:
NOVEL MRI METHODS FOR NEURONAL LOSS & IRON QUANTIFICATION IN PARKINSONS DISEASE
治疗神经元丢失的新 MRI 方法
- 批准号:
8362856 - 财政年份:2011
- 资助金额:
$ 1.93万 - 项目类别:
NOVEL MRI METHODS IRON QUALIFICATION IN PARKINSON'S DISEASE
新型 MRI 方法 帕金森病中的铁含量
- 批准号:
8170495 - 财政年份:2010
- 资助金额:
$ 1.93万 - 项目类别:
ASSESSMENT OF BRIAN IRON & NEURONAL INTEGRITY USING NOVEL T1P & T2P MRI
布莱恩·艾恩的评估
- 批准号:
8170496 - 财政年份:2010
- 资助金额:
$ 1.93万 - 项目类别:
NOVEL MRI METHODS FOR NEURONAL LOSS & IRON QUANTIFICATION IN PARKINSONS DISEASE
治疗神经元丢失的新 MRI 方法
- 批准号:
8170461 - 财政年份:2010
- 资助金额:
$ 1.93万 - 项目类别: