ASSESSMENT OF BRAIN IRON AND NEURONAL INTEGRITY USING NOVEL T1? AND T2? MRI

使用 NOVEL T1 评估脑铁和神经元完整性？

• 批准号: 8170462
• 负责人: SHALOM MICHAELI
• 金额: $ 1.93万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170462
• 关键词: Brain; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Imaging Techniques; Injection of therapeutic agent; Institution; Iron; Magnetic Resonance Imaging; Methods; Neurons; Oxidopamine; Parkinson Disease; Pathway interactions; Research; Research Personnel; Resolution; Resources; Source; Substantia nigra structure; Techniques; United States National Institutes of Health; aphakia mice; density; dopaminergic neuron; mouse model; neuron loss; novel; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project we aim to establish novel high-resolution magnetic resonance imaging (MRI) technique, T1¿, as quantitative methods sensitive to neuronal loss in the brain. We will investigate the predictive/discriminatory ability of the T1¿ using a unilateral 6-hydroxydopamine (6-OHDA) PD mouse model (intrastriatal injection of 2 ¿g 6-OHDA/¿L). We will study the functional relationship between T1¿ with neuronal density in aphakia mice (where the deficit of dopaminergic neurons in substantia nigra and the pathways for survival of neurons are well investigated). Once validated, the technique proposed here can be used as a valuable tool to investigate if and how neuronal loss in substantia nigra is correlated with the progression of Parkinson's disease.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 在这个项目中，我们旨在建立新型的高分辨率磁共振成像（MRI）技术，即对大脑神经元丧失敏感的定量方法。我们将使用单侧6-羟基多巴胺（6-OHDA）PD小鼠模型（纹状体内注射2»G 6-OHDA/¿我们将研究aphakia小鼠中T1¿一旦得到验证，这里提出的技术可以用作研究尼格拉氏菌中的神经元损失与帕金森氏病的进展是否相关的有价值的工具。