ASSESSMENT OF BRAIN IRON AND NEURONAL INTEGRITY USING NOVEL T1? AND T2? MRI

使用 NOVEL T1 评估脑铁和神经元完整性？

• 批准号: 8170462
• 负责人: SHALOM MICHAELI
• 金额: $ 1.93万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170462
• 关键词: Brain; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Imaging Techniques; Injection of therapeutic agent; Institution; Iron; Magnetic Resonance Imaging; Methods; Neurons; Oxidopamine; Parkinson Disease; Pathway interactions; Research; Research Personnel; Resolution; Resources; Source; Substantia nigra structure; Techniques; United States National Institutes of Health; aphakia mice; density; dopaminergic neuron; mouse model; neuron loss; novel; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project we aim to establish novel high-resolution magnetic resonance imaging (MRI) technique, T1¿, as quantitative methods sensitive to neuronal loss in the brain. We will investigate the predictive/discriminatory ability of the T1¿ using a unilateral 6-hydroxydopamine (6-OHDA) PD mouse model (intrastriatal injection of 2 ¿g 6-OHDA/¿L). We will study the functional relationship between T1¿ with neuronal density in aphakia mice (where the deficit of dopaminergic neurons in substantia nigra and the pathways for survival of neurons are well investigated). Once validated, the technique proposed here can be used as a valuable tool to investigate if and how neuronal loss in substantia nigra is correlated with the progression of Parkinson's disease.

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