NOVEL MRI METHODS IRON QUALIFICATION IN PARKINSON'S DISEASE
NOVEL MRI METHODS IRON QUALIFICATION IN PARKINSON'S DISEASE
批准号:
8170495
负责人:
SHALOM MICHAELI
金额:
$1.28万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-06-01 至 2011-05-31
关键词:
AreaBiological MarkersBrainBrain regionCellsComputer Retrieval of Information on Scientific Projects DatabaseDiseaseDisease modelFundingGrantInstitutionIronMagnetic Resonance ImagingMeasurementMeasuresMethodsNerve DegenerationNeurodegenerative DisordersNeuronsParkinson DiseasePathogenesisPatientsPhysiologic pulseRelaxationResearchResearch PersonnelResourcesSourceSubstantia nigra structureTechniquesUnited States National Institutes of HealthWaterdensityinsightinterestmagnetic fieldnervous system disorderneuron lossnovel
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
In this project, we plan to validate a new biomarker (adiabatic T1¿ and T2¿) measured non-invasively in the substantia nigra MRI as a means to achieve statistical separation between Parkinson's diseased (PD) patients from control subjects. The novel adiabatic T1¿ and T2¿ MRI relaxation methods proposed here for the measurement of neuronal deficiency may provide useful insights into the pathogenesis of neurological disorders, in particular PD. We demonstrated that the T1¿ relaxation measurements provide direct information about the fundamental dynamic parameters of the water spins in different areas of the brain. We show that the change in density of neurons and their projections is reflected in the tumbling of the water spins. This suggests that T1¿ measurements can potentially be used to quantify the neuronal loss in the SNc of PD patients, as well as likely other neurodegenerative conditions. The T1¿ measurements provide unique information as compared to conventional T1 MRI due to the sweep of the effective magnetic field during the adiabatic pulses used for the measurements. Further studies will be warranted to confirm the applicability of our technique to additional neurodegenerative disease models, however we expect that this technique will prove capable of detecting cell loss in any given brain region of interest.
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会议论文
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批准号:10413244
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批准号:10296096
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资助金额:$57.04万
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批准号:8362890
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项目类别:
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资助金额:$1.51万
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财政年份:2011
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负责人:SHALOM MICHAELI
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依托单位:
ASSESSMENT OF BRIAN IRON & NEURONAL INTEGRITY USING NOVEL T1P & T2P MRI
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批准号:8362891
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项目类别:
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资助金额:$1.51万
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财政年份:2011
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负责人:SHALOM MICHAELI
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依托单位:
ASSESSMENT OF BRAIN IRON AND NEURONAL INTEGRITY USING NOVEL T1? AND T2? MRI
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批准号:8362857
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项目类别:
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资助金额:$2.27万
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财政年份:2011
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负责人:SHALOM MICHAELI
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依托单位:
NOVEL MRI METHODS FOR NEURONAL LOSS & IRON QUANTIFICATION IN PARKINSONS DISEASE
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批准号:8362856
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项目类别:
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资助金额:$3.03万
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财政年份:2011
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负责人:SHALOM MICHAELI
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依托单位:
ASSESSMENT OF BRIAN IRON & NEURONAL INTEGRITY USING NOVEL T1P & T2P MRI
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批准号:8170496
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项目类别:
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资助金额:$1.28万
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财政年份:2010
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负责人:SHALOM MICHAELI
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依托单位:
NOVEL MRI METHODS FOR NEURONAL LOSS & IRON QUANTIFICATION IN PARKINSONS DISEASE
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批准号:8170461
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项目类别:
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资助金额:$2.57万
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财政年份:2010
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负责人:SHALOM MICHAELI
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依托单位:
ASSESSMENT OF BRAIN IRON AND NEURONAL INTEGRITY USING NOVEL T1? AND T2? MRI
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批准号:8170462
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项目类别:
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资助金额:$1.93万
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财政年份:2010
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负责人:SHALOM MICHAELI
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依托单位:
NOVEL MRI METHODS FOR NEURONAL LOSS & IRON QUANTIFICATION IN PARKINSONS DISEASE
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批准号:7954996
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项目类别:
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资助金额:$2.57万
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财政年份:2009
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负责人:SHALOM MICHAELI
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依托单位:
ASSESSMENT OF BRAIN IRON AND NEURONAL INTEGRITY USING NOVEL T1? AND T2? MRI
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批准号:7954997
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项目类别:
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资助金额:$1.28万
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财政年份:2009
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负责人:SHALOM MICHAELI
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依托单位:
Novel MRI Methods for Neuronal Loss and Iron Quantification in Parkinsons Disease
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批准号:7677319
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项目类别:
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资助金额:$33.03万
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财政年份:2008
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负责人:SHALOM MICHAELI
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依托单位:
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批准号:7721371
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资助金额:$5.35万
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财政年份:2008
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负责人:SHALOM MICHAELI
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依托单位:
Novel MRI Methods for Neuronal Loss and Iron Quantification in Parkinsons Disease
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批准号:7531737
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项目类别:
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资助金额:$33.03万
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财政年份:2008
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负责人:SHALOM MICHAELI
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依托单位:
Assessment of Brain Iron and Neuronal Integrity Using Novel T1r and T2r MRI
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批准号:7584641
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项目类别:
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资助金额:$19.82万
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财政年份:2008
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负责人:SHALOM MICHAELI
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依托单位:
T1? MRI CONTRAST IN THE HUMAN BRAIN ADIABATIC RF PULSE
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批准号:7721369
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项目类别:
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资助金额:$5.35万
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财政年份:2008
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负责人:SHALOM MICHAELI
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依托单位:
PROTON T2 RELAXATION: WATER, N ACETYLASPARTATE & CREATINE IN HUMAN BRAIN
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批准号:6978257
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项目类别:
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资助金额:$2.5万
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负责人:SHALOM MICHAELI
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依托单位:
海外基金