NOVEL MRI METHODS IRON QUALIFICATION IN PARKINSON'S DISEASE

新型 MRI 方法 帕金森病中的铁含量

• 批准号: 8170495
• 负责人: SHALOM MICHAELI
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170495
• 关键词: Area; Biological Markers; Brain; Brain region; Cells; Computer Retrieval of Information on Scientific Projects Database; Disease; Disease model; Funding; Grant; Institution; Iron; Magnetic Resonance Imaging; Measurement; Measures; Methods; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Parkinson Disease; Pathogenesis; Patients; Physiologic pulse; Relaxation; Research; Research Personnel; Resources; Source; Substantia nigra structure; Techniques; United States National Institutes of Health; Water; density; insight; interest; magnetic field; nervous system disorder; neuron loss; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, we plan to validate a new biomarker (adiabatic T1¿ and T2¿) measured non-invasively in the substantia nigra MRI as a means to achieve statistical separation between Parkinson's diseased (PD) patients from control subjects. The novel adiabatic T1¿ and T2¿ MRI relaxation methods proposed here for the measurement of neuronal deficiency may provide useful insights into the pathogenesis of neurological disorders, in particular PD. We demonstrated that the T1¿ relaxation measurements provide direct information about the fundamental dynamic parameters of the water spins in different areas of the brain. We show that the change in density of neurons and their projections is reflected in the tumbling of the water spins. This suggests that T1¿ measurements can potentially be used to quantify the neuronal loss in the SNc of PD patients, as well as likely other neurodegenerative conditions. The T1¿ measurements provide unique information as compared to conventional T1 MRI due to the sweep of the effective magnetic field during the adiabatic pulses used for the measurements. Further studies will be warranted to confirm the applicability of our technique to additional neurodegenerative disease models, however we expect that this technique will prove capable of detecting cell loss in any given brain region of interest.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在这个项目中，我们计划验证一种在黑质 MRI 中无创测量的新生物标志物（绝热 T1 和 T2 ），作为实现帕金森病 (PD) 患者与对照受试者之间统计分离的方法。这里提出的用于测量神经元缺陷的新型绝热 T1 和 T2 MRI 松弛方法可能为神经系统疾病，特别是 PD 的发病机制提供有用的见解。我们证明，T1 弛豫测量提供了有关大脑不同区域水自旋基本动态参数的直接信息。我们发现，神经元密度及其投射的变化反映在水自旋的翻滚中。这表明 T1¿ 测量有可能用于量化 PD 患者 SNc 中的神经元损失，以及可能的其他神经退行性疾病。与传统 T1 MRI 相比，T1¿ 测量提供了独特的信息，因为在用于测量的绝热脉冲期间扫描了有效磁场。需要进一步的研究来确认我们的技术对其他神经退行性疾病模型的适用性，但是我们预计该技术将证明能够检测任何特定大脑感兴趣区域的细胞损失。