ASSESSMENT OF BRAIN IRON AND NEURONAL INTEGRITY USING NOVEL T1? AND T2? MRI

使用 NOVEL T1 评估脑铁和神经元完整性？

• 批准号: 8362857
• 负责人: SHALOM MICHAELI
• 金额: $ 2.27万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362857
• 关键词: Brain; Funding; Grant; Imaging Techniques; Injection of therapeutic agent; Iron; Magnetic Resonance Imaging; Methods; NMR Spectroscopy; National Center for Research Resources; Neurons; Oxidopamine; Parkinson Disease; Pathway interactions; Principal Investigator; Research; Research Infrastructure; Resolution; Resources; Source; Substantia nigra structure; Techniques; United States National Institutes of Health; aphakia mice; cost; density; dopaminergic neuron; mouse model; neuron loss; novel; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In this project we aim to establish novel high-resolution magnetic resonance imaging (MRI) technique, T1¿, as quantitative methods sensitive to neuronal loss in the brain. We will investigate the predictive/discriminatory ability of the T1¿ using a unilateral 6-hydroxydopamine (6-OHDA) PD mouse model (intrastriatal injection of 2 ¿g 6-OHDA/¿L). We will study the functional relationship between T1¿ with neuronal density in aphakia mice (where the deficit of dopaminergic neurons in substantia nigra and the pathways for survival of neurons are well investigated). Once validated, the technique proposed here can be used as a valuable tool to investigate if and how neuronal loss in substantia nigra is correlated with the progression of Parkinson's disease.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在这个项目中，我们的目标是建立新的高分辨率磁共振成像（MRI）技术，T1 <$，作为定量方法敏感的神经元损失在大脑中。我们将使用单侧6-羟基多巴胺（6-OHDA）PD小鼠模型（纹状体内注射2 <$g 6-OHDA/<$L）研究T1 <$的预测/区分能力。我们将研究无晶状体小鼠（其中黑质中多巴胺能神经元的缺陷和神经元存活的途径得到了很好的研究）中T1？与神经元密度之间的功能关系。一旦验证，这里提出的技术可以被用作一个有价值的工具，以调查是否以及如何在黑质神经元的损失与帕金森氏病的进展。