ASSESSMENT OF BRIAN IRON & NEURONAL INTEGRITY USING NOVEL T1P & T2P MRI

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们在该项目中的目标是：A）使用单侧6-羟基多巴胺（6-OHDA）PD小鼠模型建立T1 ² MRI方法的预测/区分能力（纹状体内注射2 μ g 6-OHDA/μ L）; B）研究T1 ~+的能力，MRI映射识别无晶状体小鼠中受神经元损失影响的大脑区域，C）研究无晶状体小鼠黑质核、黑质核、腹侧被盖区和纹状体的T1 <$和T2 <$与神经元密度的定量关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our goals in this project are: A) to establish the predictive/discriminatory ability of the T1¿ MRI method using a unilateral 6-hydroxydopamine (6-OHDA) PD mouse model (intrastriatal injection of 2 ¿g 6-OHDA/¿L); B) To investigate the ability of T1¿ MRI mapping to recognize regions of the brain affected by neuronal loss in aphakia mice, and to investigate the quantitative relationship between T2¿ and iron loading in tissue; C) To identify the quantitative relationship between the T1¿ measurements and neuronal density, and between T2¿ and iron loading in the aphakia mouse in the SNc, SNr, VTA and striatum.