ASSESSMENT OF BRIAN IRON & NEURONAL INTEGRITY USING NOVEL T1P & T2P MRI

布莱恩·艾恩的评估

• 批准号: 8170496
• 负责人: SHALOM MICHAELI
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170496
• 关键词: Affect; Brain region; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Funding; Goals; Grant; Injection of therapeutic agent; Institution; Iron; Magnetic Resonance Imaging; Maps; Measurement; Methods; Neurons; Oxidopamine; Research; Research Personnel; Resources; Source; Tissues; United States National Institutes of Health; aphakia mice; density; mouse model; neuron loss; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goals in this project are: A) to establish the predictive/discriminatory ability of the T1¿ MRI method using a unilateral 6-hydroxydopamine (6-OHDA) PD mouse model (intrastriatal injection of 2 ¿g 6-OHDA/¿L); B) To investigate the ability of T1¿ MRI mapping to recognize regions of the brain affected by neuronal loss in aphakia mice, and to investigate the quantitative relationship between T2¿ and iron loading in tissue; C) To identify the quantitative relationship between the T1¿ measurements and neuronal density, and between T2¿ and iron loading in the aphakia mouse in the SNc, SNr, VTA and striatum.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 我们在该项目中的目标是：a）使用单方面的6-羟基多巴胺（6-OHDA）PD小鼠模型（纹状体内注射2»g 6-OHDA/¿ b）研究T1¿MRI映射能够识别Aphakia小鼠神经元丧失影响的大脑区域的能力，并研究T2¿与组织中铁负荷之间的定量关系； c）确定T1检测与神经元密度之间的定量关系，以及在SNC，SNR，VTA和纹状体中的Aphakia小鼠中T2¿和铁负荷之间的定量关系。