ANALYSIS OF CHIMPANZEE PK FOR GILEAD TLR AGONIST
ANALYSIS OF CHIMPANZEE PK FOR GILEAD TLR AGONIST
批准号:
8172717
负责人:
Robert E LANFORD
金额:
$3.09万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-04-30
关键词:
Adverse eventAgonistAnimalsBlood Chemical AnalysisBlood specimenCallithrixChronicClinical TrialsComplete Blood CountComputer Retrieval of Information on Scientific Projects DatabaseDoseFundingGrantHepatitis B VirusHepatitis C virusImmuneImmune responseInstitutionInterferonsLiverMacaca fascicularisMonitorOralPan GenusPeripheral Blood Mononuclear CellPharmaceutical PreparationsResearchResearch PersonnelResourcesSerumSourceTimeTranscriptUnited States National Institutes of HealthVirus Diseasescytokinedesignnovelsafety testing
中文摘要
该子项目是利用
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得主要资金,
因此可以在其他CRISP条目中表示。列出的机构是
中心,不一定是研究者的机构。
本研究设计为在黑猩猩中进行的一项PK/PD研究,旨在研究一种新型免疫调节剂,该免疫调节剂预期可诱导先天性免疫应答,包括IFN。该药物正在开发用于慢性病毒感染,包括HBV和HCV。已在食蟹猴和绒猴中测试了该化合物的安全性和先天免疫应答的诱导。在进行临床试验之前,需要在黑猩猩中进行剂量递增研究,以找到诱导先天免疫应答的适当水平的安全剂量。在4只黑猩猩中采用经口给药进行了4轮给药。在每轮中,通过灌胃对动物进行单次经口给药。多次采集血液样品,并评价PBMC和肝脏中先天免疫转录物的诱导以及血清中细胞因子水平。密切监测动物的不良事件,包括全血细胞计数和血液化学。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This study was designed as a PK/PD study in chimpanzees for a novel immune modulator that is expected to induce an innate immune response including IFN. The drug is being developed for chronic viral infections including HBV and HCV. The compound has been tested for safety and induction of the innate immune response in cynomolgus monkeys and marmosets. Prior to progressing to clinical trials, dose escalating studies need to be conducted in chimpanzees to find a safe dose with the appropriate level of induction of the innate immune response. Four rounds of dosing were conducted using oral dosing in four chimpanzees. In each round, the animals were given a single oral dose by gavage. Blood samples were taken at several times and evaluated for induction of innate immune transcripts in PBMC and the liver and for cytokine levels in the serum. The animals were monitored closely for adverse events including complete blood counts and blood chemistries.
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科研奖励(0)
会议论文
GBV-B: A SMALL PRIMATE MODEL FOR HEPATITIS C INFECTION
-
批准号:8357644
-
项目类别:
-
资助金额:$5.71万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
DEVELOPMENT OF A BABOON MODEL OF LIVER CANCER
-
批准号:8357717
-
项目类别:
-
资助金额:$3.56万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
NIH-Owned Chimpanzee Research Resource at the SNPRC
-
批准号:8727694
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
ANALYSIS OF CHIMPANZEE PK FOR GILEAD TLR AGONIST
-
批准号:8357690
-
项目类别:
-
资助金额:$2.41万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
EFFICACY OF TLR7 AGONIST FOR CHRONIC HBV INFECTION IN CHIMPANZEES
-
批准号:8357720
-
项目类别:
-
资助金额:$4.1万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
CONVERSION OF IFN? NULL RESPONDER PHENOTYPE IN TO IFN RESPONDER PHENOTYPE
-
批准号:8357716
-
项目类别:
-
资助金额:$7.23万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
The Innate Immune Response in the Marmoset Model of GBV-B Infections: A Surrogate
-
批准号:8497598
-
项目类别:
-
资助金额:$51.95万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
The Innate Immune Response in the Marmoset Model of GBV-B Infections: A Surrogate
-
批准号:8676647
-
项目类别:
-
资助金额:$55.27万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
MOLECULAR SWITCH VACCINES FOR BIODEFENSE, CANCER, AND INFECTIOUS DISEASE
-
批准号:8357718
-
项目类别:
-
资助金额:$3.09万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
EVALUATION OF ANTIBODY IMMUNOTHERAPY FOR HCV IN CHIMPANZEES
-
批准号:8357719
-
项目类别:
-
资助金额:$3.66万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
NIH-Owned Chimpanzee Research Resource at the SNPRC
-
批准号:8500489
-
项目类别:
-
资助金额:$65.0万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
The Innate Immune Response in the Marmoset Model of GBV-B Infections: A Surrogate
-
批准号:8298145
-
项目类别:
-
资助金额:$55.27万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
EFFICACY OF TLR7 AGONIST FOR CHRONIC HCV INFECTION IN CHIMPANZEES
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批准号:8357721
-
项目类别:
-
资助金额:$5.06万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
SOUTHEASTERN COOPERATIVE HEPATITIS C RESEARCH GROUP
-
批准号:8357641
-
项目类别:
-
资助金额:$8.05万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
HCV ANTIVIRAL TESTING IN CHIMPANZEES
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批准号:8357679
-
项目类别:
-
资助金额:$3.32万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
The Innate Immune Response in the Marmoset Model of GBV-B Infections: A Surrogate
-
批准号:8162227
-
项目类别:
-
资助金额:$54.75万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
HCV ANTIVIRAL TESTING IN CHIMPANZEES
-
批准号:8172698
-
项目类别:
-
资助金额:$18.12万
-
财政年份:2010
-
负责人:Robert E LANFORD
-
依托单位:
GBV-B: A SMALL PRIMATE MODEL FOR HEPATITIS C INFECTION
-
批准号:8172642
-
项目类别:
-
资助金额:$16.52万
-
财政年份:2010
-
负责人:Robert E LANFORD
-
依托单位:
HCV CENTER STUDIES ON INFECTIOUS HCV
-
批准号:8172651
-
项目类别:
-
资助金额:$3.94万
-
财政年份:2010
-
负责人:Robert E LANFORD
-
依托单位:
TLR LIGANDS IN GBV-B
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批准号:8172678
-
项目类别:
-
资助金额:$10.66万
-
财政年份:2010
-
负责人:Robert E LANFORD
-
依托单位:
国内基金
海外基金
Agonist-GPR119-Gs复合物的结构生物学研究
-
批准号:32000851
-
项目类别:青年科学基金项目
-
资助金额:24.0万元
-
批准年份:2020
-
负责人:乔安娜
-
依托单位: