NEW MODEL OF ASCENDING INFECTION-RELATED PREMATURE BIRTH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 早产仍然是一个重大的经济和公共卫生负担，而且发病率还在上升。感染引起的炎症在早产中起着重要作用，被认为是由于感染而发生的，感染会促进早产子宫收缩。产科研究尚未确定对早产的有效预防干预措施。这项建议的总体目标是开发一个模拟人类早产的模型系统，以最终阐明感染导致早产和相关不良新生儿后遗症(如脑损伤)的分子机制。我们建议在辫尾猕猴中建立一个非人类灵长类动物模型，该模型可以很好地模拟下生殖道感染在子宫下段-蜕膜交界处绒毛-蜕膜交界处的上升过程。中心假说是，在宫颈近端绒毛-蜕膜界面感染B组链球菌(GBS)会导致炎症反应，从而导致过早的子宫肌层收缩、羊膜内感染和早产。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm birth remains a significant economic and public health burden and the incidence is rising. Infection induced inflammation plays a significant role in preterm birth and is thought to occur as a result of infection, which promotes premature uterine contractions. Obstetrical research has yet to identify effective preventive interventions for preterm labor. The overall objective of this proposal is to develop a model system which emulates human preterm birth to ultimately elucidate molecular mechanisms of infection-induced preterm labor and related adverse neonatal sequelae (e.g. brain injury). We propose to develop a nonhuman primate model in the pigtail macaque that closely mimics an ascending lower genital tract infection at the chorio-decidual interface in the lower uterine segment-decidual interface. The central hypothesis is that infection with group B streptococcus (GBS) at the chorio-decidual interface at the proximal cervical canal will result in an inflammatory response that results in premature myometrial contractions, intra-amniotic infection, and premature delivery.