NEUROPHYSIOLOGY OF SACCADE ADAPTATION

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 扫视眼球运动的适应是必要的，这样扫视准确性可以在整个生命中保持，尽管由发育、衰老和创伤引起的变化。该资助的长期目标是研究小脑动眼蠕虫在适应过程中可能发挥的作用。我们将通过三组实验来接近这个目标。在第一个，我们将跟踪蚓部，并确定在扫视的行为适应内扫视目标步骤，这导致扫视出现不准确的赤字。在第二部分中，我们将研究眼蚓部浦肯野细胞的简单棘波活动的行为，以确定它在这种行为适应过程中是如何变化的。最后，我们将尝试通过刺激上级丘来驱动适应，这可能是下橄榄核中错误相关活动的来源。由于猿类与人类扫视性眼球运动行为的相似性，本项目的结果应对扫视性眼球运动障碍患者的诊断、治疗和康复有相当大的相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adaptation of saccadic eye movements is necessary so that saccade accuracy can be maintained throughout life despite the changes caused by development, aging and trauma. The long-term objective of this grant is to study the possible role of the oculomotor vermis of the cerebellum in the adaptation process. We will approach this object with 3 sets of experiments. In the first, we will inactivate the vermis pharmacologically and determine the deficit in the behavioral adaptation of saccades to an intra-saccadic target step, which causes saccades to appear inaccurate. In the second, we will examine the behavior of simple spike activity in the Purkinje cells of the oculomotor vermis to determine how it changes during this behavioral adaptation. Finally, we will attempt to drive adaptation by stimulating the superior colliculus, which is the likely source of the error-related activity in the inferior olive. Because of the similarities of simian and human saccadic eye movement behavior, the results of this project should have considerable relevance in the diagnosis, treatment and rehabilitation of patients with saccadic eye movement disorders.