NEUROPHYSIOLOGY OF SACCADE ADAPTATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 眼跳运动的适应是必要的，这样即使在发育、衰老和创伤引起的变化的情况下，眼跳的准确性也可以在一生中保持。这笔赠款的长期目标是研究小脑动眼蠕虫在适应过程中的可能作用。我们将通过3组实验来实现这一目标。在第一个步骤中，我们将从药物上灭活蚯蚓，并确定眼跳对眼跳内靶步骤的行为适应的缺陷，这会导致眼跳看起来不准确。在第二个实验中，我们将研究动眼蠕虫浦肯野细胞中简单棘波活动的行为，以确定它在这种行为适应过程中是如何变化的。最后，我们将试图通过刺激上丘来驱动适应，这可能是下橄榄错误相关活动的来源。由于猿猴和人类眼跳运动行为的相似性，本项目的研究结果对眼跳运动障碍患者的诊断、治疗和康复具有相当大的相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adaptation of saccadic eye movements is necessary so that saccade accuracy can be maintained throughout life despite the changes caused by development, aging and trauma. The long-term objective of this grant is to study the possible role of the oculomotor vermis of the cerebellum in the adaptation process. We will approach this object with 3 sets of experiments. In the first, we will inactivate the vermis pharmacologically and determine the deficit in the behavioral adaptation of saccades to an intra-saccadic target step, which causes saccades to appear inaccurate. In the second, we will examine the behavior of simple spike activity in the Purkinje cells of the oculomotor vermis to determine how it changes during this behavioral adaptation. Finally, we will attempt to drive adaptation by stimulating the superior colliculus, which is the likely source of the error-related activity in the inferior olive. Because of the similarities of simian and human saccadic eye movement behavior, the results of this project should have considerable relevance in the diagnosis, treatment and rehabilitation of patients with saccadic eye movement disorders.