Neurophysiology of Saccade Adaptation

描述(由申请人提供)：眼跳运动的适应是必要的，这样即使在发育、老化和创伤引起的变化的情况下，眼跳的准确性也可以在一生中保持。这笔赠款的长期目标是研究小脑动眼蠕虫(OMV)在适应过程中的可能作用。我们将通过3组实验来实现这一目标。在第一个步骤中，我们将从药物上使OMV失活，并确定眼跳对导致眼跳看起来不准确的内扫视靶步的行为适应方面的缺陷。在第二个实验中，我们将研究动眼蠕虫浦肯野细胞中简单棘波活动的行为，以确定它在这种行为适应过程中是如何变化的。最后，我们将激活可能的错误信号通路，通过刺激上丘来驱动适应，这可能是错误相关的攀爬纤维活性到OMV的来源。由于猿猴和人类眼跳运动行为的相似性，本项目的研究结果对眼跳运动障碍患者的诊断、治疗和康复具有相当大的相关性。

DESCRIPTION (provided by applicant): Adaptation of saccadic eye movements is necessary so that saccade accuracy can be maintained throughout life despite the changes caused by development, aging and trauma. The long-term objective of this grant is to study the possible role of the oculomotor vermis (OMV) of the cerebellum in the adaptation process. We will approach this objective with 3 sets of experiments. In the first, we will inactivate the OMV pharmacologically and determine the deficit in the behavioral adaptation of saccades to an intra-saccadic target step, which causes saccades to appear inaccurate. In the second, we will examine the behavior of simple spike activity in the Purkinje cells of the oculomotor vermis to determine how it changes during this behavioral adaptation. Finally, we will activate the putative error signal pathway that drives adaptation by stimulating the superior colliculus, which is the likely source of the error-related climbing fiber activity to the OMV. Because of the similarities of simian and human saccadic eye movement behavior, the results of this project should have considerable relevance in the diagnosis, treatment and rehabilitation of patients with saccadic eye movement disorders.