WATER SOLUABLE NUTRIENT ABSORPTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：通过测量水溶性营养素的被动吸收程度，更好地了解非人类灵长类动物的消化生理学。 该项目对于理解人类和非人类灵长类动物的消化生理学，以及理解脊椎动物的营养生态学和毒理学具有重要意义。许多营养素、天然毒素、合成毒素和药物都是水溶性的。水溶性化学物质穿过脊椎动物小肠的有效运输可能取决于膜运输蛋白（介导的运输）;然而，一些动物可以有效地通过细胞之间的间隙运输这些化学物质（即，通过被动的细胞旁途径）。我们使用生理学和药代动力学技术来测试灵长类动物被动吸收的程度。这项研究于2003年秋季开始，2005年12月完成。 这项研究使用WNPRC动物服务。 在本报告所述期间之前结束供资。有一份出版物待出版。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To better understand the digestive physiology of non-human primates by measuring the extent of passive absorption of water-soluble nutrients. This project has important implications for understanding the digestive physiology of humans and non-human primates, and also for understanding vertebrate nutritional ecology and toxicology. Many nutrients, natural toxins and synthetic toxins and drugs are hydrosoluble. Efficient transport of hydrosoluble chemicals across the vertebrate small intestine likely depends on membrane transport proteins (mediated transport); however, some animals can efficiently transport these chemicals through the gaps between cells (i.e., by a passive, paracellular pathway). We used physiological and pharmacokinetic techniques to test the extent of passive absorption in primates. This study began during the fall of 2003 and was completed by December of 2005. This research used WNPRC Animal Services. Funding ended before this reporting period. One publication is pending.