GENETICS OF REPRODUCTIVE SENESCENCE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的目的是建立一个研究生殖衰老遗传基础的模型系统。该项目将研究一个由500只自然衰老的成年狒狒组成的纯种群体。将通过观察监测生殖周期，并在月经周期第5天和第25天对动物流血的。这些数据和分析将确定负责衰老生殖指数变化的人类遗传区域。殖民地将提供广泛的资源，衰老病理学和基因表达谱老化。衰老狒狒的综合规模、经济、实验环境、谱系和标记集为我们进一步了解人类的衰老和健康提供了前所未有的资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this protocol is to establish a model system to study the genetic basis of reproductive aging. The project will study a pedigreed colony of 500 naturally aging adult baboons. The reproductive cycle will be monitored by observation and the animal bled on day 5 and 25 of the menstrual cycle. The data and analysis will identify human genetic regions responsible for variation in reproductive indices of senescence. The colony will provide extensive resources on senescence pathology and gene expression profiles of aging. The combined scale, economy, experimental environment, pedigree and marker set of the aging baboon offers an unprecedented resource to advance our understanding of aging and health in humans.