GENETICS OF REPRODUCTIVE SENESCENCE

生殖衰老的遗传学

• 批准号: 8172658
• 负责人: MARC TATAR
• 金额: $ 3.84万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172658
• 关键词: Adult; Aging; Animals; Biological Models; Computer Retrieval of Information on Scientific Projects Database; Data Analyses; Environment; Funding; Gene Expression; Genetic; Grant; Health; Hemorrhage; Human; Human Genetics; Institution; Menstrual cycle; Molecular Profiling; Monitor; Papio; Pathology; Protocols documentation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Variant; base; genetic pedigree; indexing; reproductive; senescence

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this protocol is to establish a model system to study the genetic basis of reproductive aging. The project will study a pedigreed colony of 500 naturally aging adult baboons. The reproductive cycle will be monitored by observation and the animal bled on day 5 and 25 of the menstrual cycle. The data and analysis will identify human genetic regions responsible for variation in reproductive indices of senescence. The colony will provide extensive resources on senescence pathology and gene expression profiles of aging. The combined scale, economy, experimental environment, pedigree and marker set of the aging baboon offers an unprecedented resource to advance our understanding of aging and health in humans.

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