Genetics of Reproductive Senescence

女性生殖衰老的标志是卵巢功能逐渐丧失，月经不规律 和内分泌平衡。生殖老化伴随着血管扩张和泌尿生殖道症状 绝经本身之前的事件，并可能导致病理生理综合征，包括 骨质疏松症和心血管疾病。对非人类灵长类动物的种群和遗传研究将 增强我们对围绝经期的理解-绝经过渡期。SFBR的雌性狒狒 特别是提供了一个独特的模型来了解人类生殖老化，因为我们可以准确地 决定其一生的月经行为从会阴肿胀，像人类一样，是非季节性的 饲养员本项目将研究个体月经动态，以量化生殖衰老状态 对于大型研究人群的所有女性，它将生成每日个体多周期的详细曲线 促性腺激素和类固醇激素。这些措施将提供基于个人的估计， 估计环境、母体和遗传成分对变异的贡献的群体尺度 生殖老化，并确定影响生殖模式和围绝经期的遗传位点。的 数据将为评估围绝经期的机制模型提供独特的机会。加上 计划范围内的身体老化的多维措施，我们将评估的程度，生殖 和躯体衰老是一致的或独立的。

Female reproductive senescence is marked by the progressive loss of ovarian function, menstrual regularity and endocrine homeostasis. Reproductive aging is accompanied by vasomotor and urogenital symptoms preceding the event of menopause itself, and can contribute to pathophysiological syndromes including osteoporosis and cardiovascular disease. Population and genetic studies of nonhuman primates will enhance how we understand perimenopause - the menopausal transition. Female baboons of SFBR in particular offer a unique model to understand human reproductive aging because we can accurately determine their life-long menstrual behavior from perineum turgescence and, like humans, are non-seasonal breeders. This Project will study individual menstrual dynamics to quantify the state of reproductive senescence for all females of the large study population, and it will generate detailed profiles of daily individual multi-cycle gonadotropic and steroid hormones. These measures will provide individual based estimates on a population scale to estimate the contribution of environment, maternal and genetic components to variation reproductive aging, and to identify genetic loci that influence reproductive patterns and perimenopause. The data will provide unique opportunities to evaluate mechanistic models for perimenopause. Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent.