GENETICS OF REPRODUCTIVE SENESCENCE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是建立一个研究生殖衰老遗传基础的模型系统。该项目将研究一个由500只自然衰老的成年狒狒组成的纯种群体。将通过观察来监测生殖周期，并在月经周期的第5天和第25天对动物流血的。这些数据和分析将确定负责衰老生殖指数变化的人类遗传区域。殖民地将提供广泛的资源，衰老病理学和基因表达谱老化。衰老狒狒的综合规模、经济、实验环境、谱系和标记集为我们进一步了解人类的衰老和健康提供了前所未有的资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this protocol is to establish a model system to study the genetic basis of reproductive aging. The project will study a pedigreed colony of 500 naturally aging adult baboons. The reproductive cycle will be monitored by observation and the animal bled on day 5 and 25 of the menstrual cycle. The data and analysis will identify human genetic regions responsible for variation in reproductive indices of senescence. The colony will provide extensive resources on senescence pathology and gene expression profiles of aging. The combined scale, economy, experimental environment, pedigree and marker set of the aging baboon offers an unprecedented resource to advance our understanding of aging and health in humans.