Genome wide association analysis with Drosophila to discover how metformin effects longevity
与果蝇的全基因组关联分析,以发现二甲双胍如何影响长寿
基本信息
- 批准号:10645126
- 负责人:
- 金额:$ 39.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdultAffectAgingAnimal ModelBioinformaticsBiological ModelsCandidate Disease GeneComplexComplex Genetic TraitDataData AnalysesDietDissectionDoseDrosophila genomeDrosophila genusExperimental GeneticsFailureGene ExpressionGene OrderGenesGeneticGenetic EpistasisGenetic VariationGenetic studyGenomicsHumanLongevityMammalsMapsMeta-AnalysisMetforminMethodsMolecularMusOrthologous GenePathway interactionsPositioning AttributeRNA InterferenceRegulationSeriesSiteSurvival AnalysisTestingTranslatingVariantWorkage relatedanalytical methodcohortexperienceflygenome wide association studyhazardinnovationknock-downmortalitynovel strategiesreference genomeresponsesegregationsemiparametricsexsuccesstraitvalidation studies
项目摘要
Summary
Drosophila can be used to discover the underlying molecular mechanisms by which metformin
effects lifespan. From 112 tested cohorts, we found metformin can extend fly lifespan as much
as 30% but in other conditions the compound equally reduced lifespan. Here we propose to
identify genetic factors that contribute to this variation. We will conduct a genome wide
association (GWA) analysis with Drosophila, combined with emerging bioinformatic analytics
and molecular validation studies. We propose as well, an innovative approach to bridge
Drosophila analysis to humans and mice by mapping response SNPs of the fly onto orthologous
gene expression data from mammals. We will combine these approaches to resolve how
metformin affects aging, and through which pathways it positively or negatively modulates
lifespan.
总结
果蝇可用于发现二甲双胍
影响寿命。从112个测试的队列中,我们发现二甲双胍可以延长苍蝇的寿命,
但在其他条件下,该化合物同样缩短了寿命。在此,我们建议
确定导致这种变异的遗传因素。我们将进行全基因组的
关联(GWA)分析与果蝇,结合新兴的生物信息学分析
和分子验证研究。我们还提出了一种创新的方法,
通过将果蝇的反应SNPs定位到orthophosphate上来分析人类和小鼠的果蝇
来自哺乳动物的基因表达数据。我们将联合收割机结合这些方法来解决如何
二甲双胍影响衰老,以及它通过哪些途径进行积极或消极调节
寿命
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARC TATAR其他文献
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{{ truncateString('MARC TATAR', 18)}}的其他基金
Genome wide association analysis with Drosophila to discover how metformin effects longevity
与果蝇的全基因组关联分析,以发现二甲双胍如何影响长寿
- 批准号:
10085915 - 财政年份:2020
- 资助金额:
$ 39.88万 - 项目类别:
Innate immune dysregulation in Alzheimer's disease modeled in Drosophila
以果蝇为模型的阿尔茨海默病的先天免疫失调
- 批准号:
10259828 - 财政年份:2020
- 资助金额:
$ 39.88万 - 项目类别:
Genome wide association analysis with Drosophila to discover how metformin effects longevity
与果蝇的全基因组关联分析,以发现二甲双胍如何影响长寿
- 批准号:
10424563 - 财政年份:2020
- 资助金额:
$ 39.88万 - 项目类别:
Genome wide association analysis with Drosophila to discover how metformin effects longevity
与果蝇的全基因组关联分析,以发现二甲双胍如何影响长寿
- 批准号:
10264139 - 财政年份:2020
- 资助金额:
$ 39.88万 - 项目类别:
Aging regulation by non-autonomous signaling from Drosophila gut enteroendocrine cells
果蝇肠道内分泌细胞非自主信号传导的衰老调节
- 批准号:
9920655 - 财政年份:2018
- 资助金额:
$ 39.88万 - 项目类别:
Aging regulation by non-autonomous signaling from Drosophila gut enteroendocrine cells
果蝇肠道内分泌细胞非自主信号传导的衰老调节
- 批准号:
10392963 - 财政年份:2018
- 资助金额:
$ 39.88万 - 项目类别:
REPTOR as a mechanism for aging control by dietary restriction and rapamycin
REPTOR作为通过饮食限制和雷帕霉素控制衰老的机制
- 批准号:
9299810 - 财政年份:2017
- 资助金额:
$ 39.88万 - 项目类别:
FUNCTIONS AND INTERACTIONS DFOXO IN DROSOPHILA AGING
DFOXO 在果蝇衰老中的功能和相互作用
- 批准号:
9901409 - 财政年份:2016
- 资助金额:
$ 39.88万 - 项目类别:
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