INTRARECTAL TITRATION OF SHIV 162P4 STOCK
INTRARECTAL TITRATION OF SHIV 162P4 STOCK
批准号:
8172740
负责人:
Shiu-Lok Hu
金额:
$46.53万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-04-30
关键词:
Antibody FormationComparative StudyComputer Retrieval of Information on Scientific Projects DatabaseEvolutionFamily suidaeFundingGenerationsGoalsGrantHIV-1InfectionInstitutionMacacaMacaca mulattaModelingMonitorPathogenicityReportingResearchResearch PersonnelResourcesRouteSourceTailTitrationsUnited States National Institutes of HealthViralVirus Diseasesin vivoneutralizing antibodysimian human immunodeficiency virus
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
We previously reported a comparative study of the in vivo infectivity and pathogenicity of a CCR5-tropic SHIVSF162 P4 in rhesus and pig-tailed macaques. Results indicate that both rhesus and pig-tailed macaques are similarly susceptible to SHIVSF162 P4 infection by mucosal routes. However, SHIV replication was significantly more robust in pig-tailed macaques than in rhesus. Since, persistent viral infection has been correlated with broadening of neutralizing antibody responses, we continued to monitor the evolution of viral sequences and neutralizing antibody activities in a subset of infected pig-tailed macaques after the primary goal of this study was achieved. Information obtained from these studies may help the establishment of macaque models to determine factors required for the generation of broadly neutralizing antibodies against HIV-1.
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专著(0)
科研奖励(0)
会议论文
VIRUS-LIKE PARTICLES WITH STABILIZED TRIMERIC ENVELOPE FOR PRIME BOOST IMMUNIZATION
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批准号:9530535
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项目类别:
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资助金额:$61.53万
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财政年份:2017
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负责人:Shiu-Lok Hu
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依托单位:
PROTECTIVE EFFICACY OF GLYCAN-MODIFIED ENV VACCINE
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批准号:8357597
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项目类别:
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资助金额:$37.79万
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财政年份:2011
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负责人:Shiu-Lok Hu
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依托单位:
Recombinant Protein Immunogens
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批准号:8327071
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项目类别:
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资助金额:$33.65万
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财政年份:2011
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负责人:Shiu-Lok Hu
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依托单位:
IMMUNOPATHOGENESIS OF CLADE C SHIV-1157IPD3N4 IN M NEMESTRINA
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批准号:8357596
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项目类别:
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资助金额:$37.79万
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财政年份:2011
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负责人:Shiu-Lok Hu
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依托单位:
INFECTIVITY OF HSIV-VIF CHIMERA IN PIGTAILED MACAQUES
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批准号:8357599
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项目类别:
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资助金额:$37.79万
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财政年份:2011
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负责人:Shiu-Lok Hu
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依托单位:
COMBINED APPROACH TO BROADLY PROTECTIVE AIDS VACCINES: PROJECT 4
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批准号:8357598
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项目类别:
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资助金额:$37.79万
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财政年份:2011
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负责人:Shiu-Lok Hu
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依托单位:
Nonhuman Primate Core
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批准号:8202348
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项目类别:
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资助金额:$108.48万
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财政年份:2011
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负责人:Shiu-Lok Hu
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依托单位:
INFECTIVITY OF HSIV-VIF CHIMERA IN NEWBORN PIGTAILED MACAQUES
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批准号:8357619
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项目类别:
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资助金额:$37.79万
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财政年份:2011
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负责人:Shiu-Lok Hu
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依托单位:
INTRARECTAL TITRATION OF SHIV 162P4 STOCK
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批准号:8357586
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项目类别:
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资助金额:$32.86万
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财政年份:2011
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负责人:Shiu-Lok Hu
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依托单位:
ORIGIN AND EVOLUTION OF HIV-1 DRUG RESISTANCE
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批准号:8357636
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项目类别:
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资助金额:$37.79万
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财政年份:2011
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负责人:Shiu-Lok Hu
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依托单位:
COMBINED APPROACH TO BROADLY PROTECTIVE AIDS VACCINES: PROJECT 4
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批准号:8172760
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项目类别:
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资助金额:$46.53万
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财政年份:2010
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负责人:Shiu-Lok Hu
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依托单位:
INFECTIVITY OF HSIV-VIF CHIMERA IN PIGTAILED MACAQUES
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批准号:8172761
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项目类别:
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资助金额:$46.53万
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财政年份:2010
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负责人:Shiu-Lok Hu
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依托单位:
Oral immunization against HIV/AIDS with prime-boost strategies
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批准号:7995820
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项目类别:
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资助金额:$53.81万
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财政年份:2010
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负责人:Shiu-Lok Hu
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依托单位:
COMBINED APPROACH TO BROADLY PROTECTIVE AIDS VACCINES: CORE B
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批准号:8172758
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项目类别:
-
资助金额:$46.53万
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财政年份:2010
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负责人:Shiu-Lok Hu
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依托单位:
Oral immunization against HIV/AIDS with prime-boost strategies
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批准号:8383064
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项目类别:
-
资助金额:$69.2万
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财政年份:2010
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负责人:Shiu-Lok Hu
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依托单位:
Oral immunization against HIV/AIDS with prime-boost strategies
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批准号:8774838
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项目类别:
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资助金额:$60.46万
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财政年份:2010
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负责人:Shiu-Lok Hu
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依托单位:
EFFICACY OF GLYCAN-MODIFIED ENV VACCINES AGAINST HETEROLOGOUS SHIV CHALLENGE
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批准号:8172759
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项目类别:
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资助金额:$46.53万
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财政年份:2010
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负责人:Shiu-Lok Hu
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依托单位:
Oral immunization against HIV/AIDS with prime-boost strategies
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批准号:8580930
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项目类别:
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资助金额:$76.5万
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财政年份:2010
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负责人:Shiu-Lok Hu
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依托单位:
Strategies for inducing bnAbs against QNES by infection with SHIVs
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批准号:7904633
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项目类别:
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资助金额:$61.7万
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财政年份:2010
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负责人:Shiu-Lok Hu
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依托单位:
INFECTIVITY OF HSIV-VIF CHIMERA IN NEWBORN PIGTAILED MACAQUES
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批准号:8172792
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项目类别:
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资助金额:$46.53万
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财政年份:2010
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负责人:Shiu-Lok Hu
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依托单位:
海外基金