ORIGIN AND EVOLUTION OF HIV-1 DRUG RESISTANCE

HIV-1 耐药性的起源和演变

基本信息

  • 批准号:
    8357636
  • 负责人:
  • 金额:
    $ 37.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Drug resistance is a significant issue affecting the treatment options of individuals infected with HIV-1. Some drug resistance-conferring mutations can persist for long periods in the host and can be transmitted horizontally and/or vertically to new individuals. How drug resistance-conferring mutations arise during treatment, particularly in anatomical sites other than the blood, is not understood and may affect transmission of drug resistant HIV-1 and persistence of viral reservoirs throughout the body. To date, no studies have longitudinally sampled blood and different anatomical compartments to identify the origins and emergence of drug resistant isolates and to measure antiretroviral drug concentrations at those same sites. In this subcontract, we propose to use a RT-SHIVmne infection model in pig-tailed macaques to study the origin and evolution of HIV-1 drug resistance. The Specific Aims of this project are: (1): To examine longitudinally the emergence of drug resistance-conferring mutations in RT that arise in RT-SHIVmne-infected macaques receiving monotherapy with the nucleoside analog FTC , or the non-nucleoside RT inhibitor efavirenz, in blood and different anatomical compartments; (2): To determine the tissue origin of the re-emergence of wild-type virus and/or persistence of drug resistant virus after discontinuation of monotherapy and after suppression of viremia with combination antiretroviral therapy in the RT-SHIVmne-infected animals; (3): To measure the concentration of antiretroviral drugs in the blood and tissue compartments of RT-SHIVmne-infected macaques described above and correlate these with emergence of resistance. In vivo studies in Specific Aim 1 were initiated in January of 2011.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Shiu-Lok Hu其他文献

Shiu-Lok Hu的其他文献

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{{ truncateString('Shiu-Lok Hu', 18)}}的其他基金

VIRUS-LIKE PARTICLES WITH STABILIZED TRIMERIC ENVELOPE FOR PRIME BOOST IMMUNIZATION
具有稳定三聚体包膜的病毒样颗粒,用于初免加强免疫
  • 批准号:
    9530535
  • 财政年份:
    2017
  • 资助金额:
    $ 37.79万
  • 项目类别:
PROTECTIVE EFFICACY OF GLYCAN-MODIFIED ENV VACCINE
聚糖修饰的 ENV 疫苗的保护作用
  • 批准号:
    8357597
  • 财政年份:
    2011
  • 资助金额:
    $ 37.79万
  • 项目类别:
Recombinant Protein Immunogens
重组蛋白免疫原
  • 批准号:
    8327071
  • 财政年份:
    2011
  • 资助金额:
    $ 37.79万
  • 项目类别:
IMMUNOPATHOGENESIS OF CLADE C SHIV-1157IPD3N4 IN M NEMESTRINA
M Nemestrina 中 C 进化枝 SHIV-1157IPD3N4 的免疫发病机制
  • 批准号:
    8357596
  • 财政年份:
    2011
  • 资助金额:
    $ 37.79万
  • 项目类别:
INFECTIVITY OF HSIV-VIF CHIMERA IN PIGTAILED MACAQUES
HSIV-VIF 嵌合体在斑尾猕猴中的感染性
  • 批准号:
    8357599
  • 财政年份:
    2011
  • 资助金额:
    $ 37.79万
  • 项目类别:
COMBINED APPROACH TO BROADLY PROTECTIVE AIDS VACCINES: PROJECT 4
广泛保护性艾滋病疫苗的综合方法:项目 4
  • 批准号:
    8357598
  • 财政年份:
    2011
  • 资助金额:
    $ 37.79万
  • 项目类别:
Nonhuman Primate Core
非人类灵长类核心
  • 批准号:
    8202348
  • 财政年份:
    2011
  • 资助金额:
    $ 37.79万
  • 项目类别:
INFECTIVITY OF HSIV-VIF CHIMERA IN NEWBORN PIGTAILED MACAQUES
HSIV-VIF 嵌合体在新生短尾猴中的感染性
  • 批准号:
    8357619
  • 财政年份:
    2011
  • 资助金额:
    $ 37.79万
  • 项目类别:
INTRARECTAL TITRATION OF SHIV 162P4 STOCK
SHIV 162P4 库存的直肠内滴定
  • 批准号:
    8357586
  • 财政年份:
    2011
  • 资助金额:
    $ 37.79万
  • 项目类别:
INTRARECTAL TITRATION OF SHIV 162P4 STOCK
SHIV 162P4 库存的直肠内滴定
  • 批准号:
    8172740
  • 财政年份:
    2010
  • 资助金额:
    $ 37.79万
  • 项目类别:

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动物对陆地的最早探索:从痕迹化石到数值分析
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