IN VIVO EVALUATION OF PRIMATE LENTIVIRUSES

灵长类慢病毒的体内评估

• 批准号: 8172752
• 负责人: DAVID M ANDERSON
• 金额: $ 46.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172752
• 关键词: AIDS Vaccines; Accounting; Chinese People; Computer Retrieval of Information on Scientific Projects Database; Evaluation; Funding; Future; Grant; HIV-1; Immune response; Infection; Institution; Macaca mulatta; Measures; Primate Lentiviruses; Research; Research Personnel; Resources; Route; Source; T-Lymphocyte; United States National Institutes of Health; Vaccines; Virus; in vivo; microbicide

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV-1 clade C virus accounts for greater than 50% of all infections worldwide. Thus, the opportunity to study this subtype in the context of candidate AIDS vaccines is especially valuable. The current study measured the infectivity and inductive ability of B- and T-cell immune responses by the intravaginal route so that these SHIVs may serve as challenge viruses in future vaccine studies and microbicide trials in Chinese rhesus macaques utilizing this route of infection.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 HIV-1 C分支病毒占全球所有感染的50%以上。 因此，在候选艾滋病疫苗的背景下研究这种亚型的机会特别有价值。 目前的研究测量的感染性和诱导能力的B-和T-细胞免疫反应的阴道内途径，使这些SHIV可作为挑战病毒在未来的疫苗研究和杀微生物剂试验中，在中国恒河猴利用这种感染途径。