MECHANISM OF PROTECTIVE IMMUNITY INDUCED BY EBOLA VACCINES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是通过测量VSV-ZEBOVgp赋予的抗病毒抗体和T细胞应答的贡献，来询问埃博拉出血热NHP模型中免疫的决定因素。这将通过揭示CD 8 T细胞与该疫苗在小鼠中引起的抗体应答的作用来实现。束状的

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this study is to interrogate the determinants of immunity in the NHP model of Ebola hemorrhagic fever, by measuring the contribution of antiviral antibody and T cell responses conferred by VSV-ZEBOVgp. This will be accomplished by uncovering the role of CD8 T cell versus antibody response elicited by this vaccine in m. fascicularis.