WANPRC MACACA NEMESTRINA SPF BREEDING COLONY

WANPRC 猕猴桃 SPF 育种群

• 批准号: 8356908
• 负责人: DAVID M ANDERSON
• 金额: $ 184.47万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356908
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Biomedical Research; Breeding; Diagnostic; Ensure; Evaluation; Foundations; Funding; Grant; Housing; Human Resources; Immunology; Institution; Laboratories; Local Microbicides; Macaca; Macaca nemestrina; Maintenance; Morbidity - disease rate; National Center for Research Resources; Pathogenesis; Primates; Principal Investigator; Process; Research; Research Infrastructure; Research Personnel; Resources; SIV; Solid; Source; Specific Pathogen Frees; Texas; Therapeutic Agents; Tuberculosis; United States National Institutes of Health; Viral; Washington; animal breeding; cost; germ free condition; laboratory facility; meetings; mortality; public health relevance; transmission process; vaccine development; virology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Macaca nemestrina are an invaluable resource for AIDS-related studies in vaccine development, therapeutic agent discovery, topical microbicide evaluation, and basic lentiviral virology, pathogenesis and immunology. The Washington National Primate Research Center (WaNPRC) seeks support to extend maintenance and continue expansion of the existing M. nemestrina specific pathogen-free breeding (SPF) colony. This colony is free of several viral agents (SIV, SRV, STLV, CHV) and tuberculosis. We seek support to expand the colony to more fully meet NIH research needs at WaNPRC and elsewhere. This proposal extends successful management and housing practices developed over the course of the previous grant which provide a solid, proven foundation for continued expansion of the colony. The existing SPF animals will be relocated as needed to consolidate the SPF M. nemestrina breeding colony at the Shin Nippon Biomedical Laboratory facility at Alice, Texas. Virologic surveillance will continue to be provided by the WaNPRC Diagnostic Laboratory and management will continue as an integrated process between WaNPRC and SNBL personnel. This foundation will be expanded to ensure continued successful expansion of this important SPF macaque colony. PUBLIC HEALTH RELEVANCE (provided by applicant): The M. nemestrina is an important, highly relevant species for AIDS-related biomedical research. Animals from this SPF colony are distributed widely; the majority provided to Affiliate Investigators, and significant numbers provided to other collaborative institutions. Additionally, SPF animals significantly limit the potential morbidity and/or mortality associated with zoonotic CHV transmission.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 描述（由申请人提供）：猕猴是疫苗开发、治疗剂发现、局部杀菌剂评估以及基础慢病毒学、发病机制和免疫学领域艾滋病相关研究的宝贵资源。华盛顿国家灵长类动物研究中心 (WaNPRC) 寻求支持，以延长维护并继续扩大现有的 M. nemestrina 特定无病原体繁殖 (SPF) 群体。该群体不含多种病毒因子（SIV、SRV、STLV、CHV）和结核病。我们寻求支持以扩大群体，以更充分地满足 NIH 在 WaNPRC 和其他地方的研究需求。该提案扩展了先前拨款过程中开发的成功管理和住房实践，为殖民地的持续扩张提供了坚实、经过验证的基础。现有的 SPF 动物将根据需要重新安置，以巩固德克萨斯州爱丽丝市新日本生物医学实验室设施的 SPF M. nemestrina 繁殖群。 WaNPRC 诊断实验室将继续提供病毒学监测，管理将继续作为 WaNPRC 和 SNBL 人员之间的综合流程。该基金会将得到扩大，以确保这一重要的 SPF 猕猴群体的持续成功扩张。 公共卫生相关性（由申请人提供）：M. nemestrina 是与艾滋病相关的生物医学研究中重要且高度相关的物种。该 SPF 群体的动物分布广泛；大部分提供给附属研究人员，还有大量提供给其他合作机构。此外，SPF 动物显着限制了与人畜共患 CHV 传播相关的潜在发病率和/或死亡率。