WANPRC MACACA NEMESTRINA SPF BREEDING COLONY

WANPRC 猕猴桃 SPF 育种群

• 批准号: 8356908
• 负责人: DAVID M ANDERSON
• 金额: $ 184.47万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356908
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Biomedical Research; Breeding; Diagnostic; Ensure; Evaluation; Foundations; Funding; Grant; Housing; Human Resources; Immunology; Institution; Laboratories; Local Microbicides; Macaca; Macaca nemestrina; Maintenance; Morbidity - disease rate; National Center for Research Resources; Pathogenesis; Primates; Principal Investigator; Process; Research; Research Infrastructure; Research Personnel; Resources; SIV; Solid; Source; Specific Pathogen Frees; Texas; Therapeutic Agents; Tuberculosis; United States National Institutes of Health; Viral; Washington; animal breeding; cost; germ free condition; laboratory facility; meetings; mortality; public health relevance; transmission process; vaccine development; virology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Macaca nemestrina are an invaluable resource for AIDS-related studies in vaccine development, therapeutic agent discovery, topical microbicide evaluation, and basic lentiviral virology, pathogenesis and immunology. The Washington National Primate Research Center (WaNPRC) seeks support to extend maintenance and continue expansion of the existing M. nemestrina specific pathogen-free breeding (SPF) colony. This colony is free of several viral agents (SIV, SRV, STLV, CHV) and tuberculosis. We seek support to expand the colony to more fully meet NIH research needs at WaNPRC and elsewhere. This proposal extends successful management and housing practices developed over the course of the previous grant which provide a solid, proven foundation for continued expansion of the colony. The existing SPF animals will be relocated as needed to consolidate the SPF M. nemestrina breeding colony at the Shin Nippon Biomedical Laboratory facility at Alice, Texas. Virologic surveillance will continue to be provided by the WaNPRC Diagnostic Laboratory and management will continue as an integrated process between WaNPRC and SNBL personnel. This foundation will be expanded to ensure continued successful expansion of this important SPF macaque colony. PUBLIC HEALTH RELEVANCE (provided by applicant): The M. nemestrina is an important, highly relevant species for AIDS-related biomedical research. Animals from this SPF colony are distributed widely; the majority provided to Affiliate Investigators, and significant numbers provided to other collaborative institutions. Additionally, SPF animals significantly limit the potential morbidity and/or mortality associated with zoonotic CHV transmission.

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