WANPRC MACACA NEMESTRINA SPF BREEDING COLONY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 描述(由申请人提供)：猕猴是艾滋病相关研究的宝贵资源，可用于疫苗开发、治疗剂发现、局部杀微生物剂评估以及基本慢病毒病毒学、发病机制和免疫学。华盛顿国家灵长类动物研究中心(WaNPRC)寻求支持，以延长维护和继续扩大现有的无病原体繁殖(SPF)群。该菌落不含几种病毒剂(SIV、SRV、STLV、CHV)和结核病。我们寻求支持，以扩大殖民地，以更充分地满足国家卫生研究院在WaNPRC和其他地方的研究需求。这项建议延续了在前一次拨款过程中发展起来的成功的管理和住房做法，这些做法为殖民地的继续扩张提供了坚实、可靠的基础。现有的SPF动物将根据需要重新安置，以巩固位于德克萨斯州爱丽斯市的Shin Nippon生物医学实验室的SPF Nememstrina繁殖群体。病毒学监测将继续由WaNPRC诊断实验室提供，管理将继续作为WaNPRC和SNBL人员之间的综合程序。这一基础将扩大，以确保这个重要的SPF猕猴群体继续成功扩张。 公共卫生相关性(由申请人提供)：新月形分枝杆菌是艾滋病相关生物医学研究中一个重要的、高度相关的物种。来自SPF群体的动物分布广泛；大多数提供给附属调查人员，大量提供给其他合作机构。此外，SPF动物显著限制了与人畜共患CHV传播相关的潜在发病率和/或死亡率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Macaca nemestrina are an invaluable resource for AIDS-related studies in vaccine development, therapeutic agent discovery, topical microbicide evaluation, and basic lentiviral virology, pathogenesis and immunology. The Washington National Primate Research Center (WaNPRC) seeks support to extend maintenance and continue expansion of the existing M. nemestrina specific pathogen-free breeding (SPF) colony. This colony is free of several viral agents (SIV, SRV, STLV, CHV) and tuberculosis. We seek support to expand the colony to more fully meet NIH research needs at WaNPRC and elsewhere. This proposal extends successful management and housing practices developed over the course of the previous grant which provide a solid, proven foundation for continued expansion of the colony. The existing SPF animals will be relocated as needed to consolidate the SPF M. nemestrina breeding colony at the Shin Nippon Biomedical Laboratory facility at Alice, Texas. Virologic surveillance will continue to be provided by the WaNPRC Diagnostic Laboratory and management will continue as an integrated process between WaNPRC and SNBL personnel. This foundation will be expanded to ensure continued successful expansion of this important SPF macaque colony. PUBLIC HEALTH RELEVANCE (provided by applicant): The M. nemestrina is an important, highly relevant species for AIDS-related biomedical research. Animals from this SPF colony are distributed widely; the majority provided to Affiliate Investigators, and significant numbers provided to other collaborative institutions. Additionally, SPF animals significantly limit the potential morbidity and/or mortality associated with zoonotic CHV transmission.