POST-EXPOSURE MONITORING OF LENTIVIRUS-INFECTED MACAQUES

慢病毒感染猕猴的暴露后监测

• 批准号: 8172754
• 负责人: DAVID M ANDERSON
• 金额: $ 46.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172754
• 关键词: Animals; Blood; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug Evaluation; Funding; Grant; HIV; Institution; Macaca; Monitor; Pathogenesis; Research; Research Personnel; Resources; SIV; Serologic tests; Serum; Source; Subfamily lentivirinae; T-Lymphocyte Subsets; United States National Institutes of Health; Vaccines; Viral; design; immunosuppressed

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is designed to act as a holding and resource project for animals that have been infected with SIV or HIV that are no longer required on the original project. The animals will be maintained in an ABSL-2/3 facilities. They will be monitored clinically to help define the natural pathogenesis of the disease. The animals may be reassigned to other projects in experimental drug evaluations, pathogenesis studies, vaccine studies, or studies requiring immunosuppressed and/or SIV/HIV-viremic animals. Blood will be drawn every 2-3 months for viral isolation, serology, CBC, serum chemistry, and T- cell subset analysis.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这个项目的目的是作为一个持有和资源项目的动物已感染SIV或艾滋病毒，不再需要在原来的项目。动物将在ABSL-2/3设施中饲养。他们将在临床上进行监测，以帮助确定疾病的自然发病机制。这些动物可能被重新分配到其他项目中，用于实验药物评价、发病机制研究、疫苗研究或需要免疫抑制和/或SIV/HIV病毒血症动物的研究。 每2-3个月抽取血液进行病毒分离、血清学、CBC、血清化学和T细胞亚群分析。