POST-EXPOSURE MONITORING OF LENTIVIRUS-INFECTED MACAQUES

慢病毒感染猕猴的暴露后监测

• 批准号: 8172754
• 负责人: DAVID M ANDERSON
• 金额: $ 46.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172754
• 关键词: Animals; Blood; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug Evaluation; Funding; Grant; HIV; Institution; Macaca; Monitor; Pathogenesis; Research; Research Personnel; Resources; SIV; Serologic tests; Serum; Source; Subfamily lentivirinae; T-Lymphocyte Subsets; United States National Institutes of Health; Vaccines; Viral; design; immunosuppressed

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is designed to act as a holding and resource project for animals that have been infected with SIV or HIV that are no longer required on the original project. The animals will be maintained in an ABSL-2/3 facilities. They will be monitored clinically to help define the natural pathogenesis of the disease. The animals may be reassigned to other projects in experimental drug evaluations, pathogenesis studies, vaccine studies, or studies requiring immunosuppressed and/or SIV/HIV-viremic animals. Blood will be drawn every 2-3 months for viral isolation, serology, CBC, serum chemistry, and T- cell subset analysis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目旨在充当已感染原始项目不再需要SIV或HIV的动物的持有和资源项目。这些动物将保持在ABSL-2/3设施中。将在临床上对其进行监测，以帮助定义疾病的自然发病机理。在实验药物评估，发病机理研究，疫苗研究或需要免疫抑制和/或SIV/SIV/HIV病毒性动物的研究中，这些动物可以重新分配到其他项目。 每2-3个月将每2-3个月抽血，以进行病毒分离，血清学，CBC，血清化学和T细胞子集分析。