POST-EXPOSURE MONITORING OF LENTIVIRUS-INFECTED MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目旨在作为原始项目不再需要的已感染SIV或HIV的动物的保留和资源项目。这些动物将被饲养在ABSL-2/3设施中。将对它们进行临床监测，以帮助确定疾病的自然发病机制。这些动物可以被重新分配到其他项目中，进行实验性药物评估、发病机制研究、疫苗研究，或者需要免疫抑制和/或SIV/HIV-病毒型动物的研究。 每2-3个月采一次血，进行病毒分离、血清学、血细胞计数、血清化学和T细胞亚群分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is designed to act as a holding and resource project for animals that have been infected with SIV or HIV that are no longer required on the original project. The animals will be maintained in an ABSL-2/3 facilities. They will be monitored clinically to help define the natural pathogenesis of the disease. The animals may be reassigned to other projects in experimental drug evaluations, pathogenesis studies, vaccine studies, or studies requiring immunosuppressed and/or SIV/HIV-viremic animals. Blood will be drawn every 2-3 months for viral isolation, serology, CBC, serum chemistry, and T- cell subset analysis.