SIV CARDIOMYOPATHY: PATHOGENESIS AND PREVENTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 我们的合作继续关注非人灵长类动物SIV感染心血管并发症的机制。这项工作集中在SIV感染和饮食的作用，主要是胰岛素抵抗，血脂异常和脂肪代谢障碍的发展。这项工作引起了从最初的重点免疫介导的心肌损伤和心肌炎的机制在SIV感染的代谢并发症和动脉粥样硬化的发病机制目前的重点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our collaboration has continued to focus on the mechanisms of cardiovascular complications with SIV infection in non human primates. This work has focused on the role of SIV infection and diet, principally on the development of insulin resistance, dyslipidemia, and lipodystrophy. The work has evoked from an initial focus on immune mediated myocardial injury and the mechanisms of myocarditis in SIV infection to the current focus on metabolic complications and the pathogenesis of atherosclerosis.