SIV CARDIOMYOPATHY: PATHOGENESIS AND PREVENTION

SIV 心肌病：发病机制和预防

• 批准号: 8172808
• 负责人: Richard P Shannon
• 金额: $ 6.58万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172808
• 关键词: Atherosclerosis; Cardiomyopathies; Cardiovascular system; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Development; Diet; Dyslipidemias; Funding; Grant; Immune; Infection; Injury; Institution; Insulin Resistance; Lipodystrophy; Mediating; Metabolic; Myocardial; Myocarditis; Pathogenesis; Prevention; Research; Research Personnel; Resources; Role; SIV; Source; United States National Institutes of Health; Work; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our collaboration has continued to focus on the mechanisms of cardiovascular complications with SIV infection in non human primates. This work has focused on the role of SIV infection and diet, principally on the development of insulin resistance, dyslipidemia, and lipodystrophy. The work has evoked from an initial focus on immune mediated myocardial injury and the mechanisms of myocarditis in SIV infection to the current focus on metabolic complications and the pathogenesis of atherosclerosis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们的合作继续关注非人类灵长类动物中SIV感染的心血管并发症的机制。这项工作集中在SIV感染和饮食的作用上，主要是胰岛素抵抗，血脂异常和脂肪营养不良的发展。这项工作从最初的关注免疫介导的心肌损伤和SIV感染中心肌炎的机制到当前对代谢并发症的关注和动脉粥样硬化的发病机理。