SIV CARDIOMYOPATHY: PATHOGENESIS AND PREVENTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的合作继续集中在非人类灵长类动物感染SIV引起的心血管并发症的机制上。这项工作的重点是SIV感染和饮食的作用，主要是胰岛素抵抗、血脂异常和脂肪营养不良的发展。这项工作从最初对免疫介导的心肌损伤和SIV感染中心肌炎的机制的关注，到目前对代谢并发症和动脉粥样硬化发病机制的关注。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our collaboration has continued to focus on the mechanisms of cardiovascular complications with SIV infection in non human primates. This work has focused on the role of SIV infection and diet, principally on the development of insulin resistance, dyslipidemia, and lipodystrophy. The work has evoked from an initial focus on immune mediated myocardial injury and the mechanisms of myocarditis in SIV infection to the current focus on metabolic complications and the pathogenesis of atherosclerosis.