SIV CARDIOMYOPATHY: PATHOGENESIS AND PREVENTION

SIV 心肌病：发病机制和预防

• 批准号: 7715431
• 负责人: Richard P Shannon
• 金额: $ 23.79万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715431
• 关键词: Acquired Immunodeficiency Syndrome; Cardiac; Cardiomyopathies; Cardiovascular system; Chronic; Computer Retrieval of Information on Scientific Projects Database; Curiosities; Funding; Grant; HIV; HIV Infections; Heart Diseases; Highly Active Antiretroviral Therapy; Individual; Institution; Life; Morbidity - disease rate; Pathogenesis; Pathologic; Pathology; Patients; Predisposition; Prevention; Research; Research Personnel; Resources; Risk Factors; Source; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV associated cardiac pathology is being recognized increasingly as patients with chronic HIV infection survives to live productive lives. HIV associated cardiomyopathy is among the most common cardiac specific manifestation of chronic HIV infection and was observed in between 6-12% of patients that succumb to AIDS. However, cardiovascular involvement has emerges as more than a pathologic curiosity, but rather as a significant cause of morbidity as individuals live longer, more productive lives with HIV. Increased use of HAART therapy has served to unmask HIV associated predispositions to cardiac involvement. Despite the increased recognition, the risks factors for, the pathogenesis of, and the specific treatments required in HIV associated cardiac disease remain unknown.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 随着慢性艾滋病毒感染患者的生存，艾滋病毒相关的心脏病理学越来越多地被认识到。 HIV相关性心肌病是慢性HIV感染最常见的心脏特异性表现之一，在6-12%死于AIDS的患者中观察到。 然而，心血管受累已不仅仅是一种病理学上的好奇心，而是一个重要的发病原因，因为艾滋病毒感染者的寿命更长，生活更有成效。 HAART治疗的使用越来越多，有助于揭示HIV相关的心脏受累倾向。 尽管认识有所增加，但HIV相关心脏病的危险因素、发病机制和所需的具体治疗仍然未知。