SIV CARDIOMYOPATHY: PATHOGENESIS AND PREVENTION

SIV 心肌病：发病机制和预防

• 批准号: 7562005
• 负责人: Richard P Shannon
• 金额: $ 19.06万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562005
• 关键词: Acquired Immunodeficiency Syndrome; Cardiac; Cardiomyopathies; Cardiovascular system; Chronic; Computer Retrieval of Information on Scientific Projects Database; Curiosities; Funding; Grant; HIV; HIV Infections; Heart Diseases; Highly Active Antiretroviral Therapy; Individual; Institution; Life; Morbidity - disease rate; Pathogenesis; Pathologic; Pathology; Patients; Predisposition; Prevention; Research; Research Personnel; Resources; Risk Factors; Source; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV associated cardiac pathology is being recognized increasingly as patients with chronic HIV infection survive to live productive lives. HIV associated cardiomyopathy is among the most common cardiac specific manifestation of chronic HIV infection and was observed in between 6-12% of patients that succumb to AIDS. However, cardiovascular involvement has emerged as more than a pathologic curiosity, but rather as a significant cause of morbidity as individuals live longer, more productive lives with HIV. Increased use of HAART therapy has served to unmask HIV associated predispositions to cardiac involvement. Despite the increased recognition, the risks factors for, the pathogenesis of, and the specific treatments required in HIV associated cardiac disease remain unknown.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 随着慢性 HIV 感染患者能够生存并过上富有成效的生活，HIV 相关的心脏病学越来越受到人们的认识。 HIV 相关心肌病是慢性 HIV 感染最常见的心脏特异性表现之一，在 6-12% 死于 AIDS 的患者中观察到。然而，心血管受累已不仅仅是一种病理学好奇心，而是一个重要的发病原因，因为感染艾滋病毒的人寿命更长、生活更富有成效。 HAART 治疗的增加使用有助于揭示与 HIV 相关的心脏受累倾向。尽管认识不断提高，但 HIV 相关心脏病的风险因素、发病机制以及所需的具体治疗方法仍然未知。