SIV CARDIOMYOPATHY: PATHOGENESIS AND PREVENTION

SIV 心肌病：发病机制和预防

• 批准号: 7562005
• 负责人: Richard P Shannon
• 金额: $ 19.06万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562005
• 关键词: Acquired Immunodeficiency Syndrome; Cardiac; Cardiomyopathies; Cardiovascular system; Chronic; Computer Retrieval of Information on Scientific Projects Database; Curiosities; Funding; Grant; HIV; HIV Infections; Heart Diseases; Highly Active Antiretroviral Therapy; Individual; Institution; Life; Morbidity - disease rate; Pathogenesis; Pathologic; Pathology; Patients; Predisposition; Prevention; Research; Research Personnel; Resources; Risk Factors; Source; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV associated cardiac pathology is being recognized increasingly as patients with chronic HIV infection survive to live productive lives. HIV associated cardiomyopathy is among the most common cardiac specific manifestation of chronic HIV infection and was observed in between 6-12% of patients that succumb to AIDS. However, cardiovascular involvement has emerged as more than a pathologic curiosity, but rather as a significant cause of morbidity as individuals live longer, more productive lives with HIV. Increased use of HAART therapy has served to unmask HIV associated predispositions to cardiac involvement. Despite the increased recognition, the risks factors for, the pathogenesis of, and the specific treatments required in HIV associated cardiac disease remain unknown.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 随着慢性艾滋病毒感染患者活下来过上有成效的生活，艾滋病毒相关的心脏病理越来越被认识到。HIV相关性心肌病是慢性HIV感染最常见的心脏特异性表现之一，在死于艾滋病的患者中可观察到6-12%。然而，心血管疾病已经不仅仅是一种病理上的好奇，而是一种重要的致病原因，因为感染艾滋病毒的人可以活得更长、更有成效。HAART治疗的增加有助于揭示HIV相关心脏受累的易感性。尽管人们对艾滋病毒相关心脏病的认识有所增加，但艾滋病毒相关心脏病的风险因素、发病机制和所需的具体治疗仍不清楚。