SIV CARDIOMYOPATHY: PATHOGENESIS AND PREVENTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 随着慢性HIV感染患者的存活率不断提高，HIV相关的心脏病理学正日益得到认可。HIV相关性心肌病是慢性HIV感染最常见的心脏特异性表现之一，在6-12%死于AIDS的患者中观察到。然而，心血管受累已不仅仅是一种病理学上的好奇心，而是一个重要的发病原因，因为艾滋病毒感染者的寿命更长，生活更有成效。HAART治疗的使用越来越多，有助于揭示HIV相关的心脏受累倾向。尽管认识有所增加，但HIV相关心脏病的危险因素、发病机制和所需的具体治疗仍然未知。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV associated cardiac pathology is being recognized increasingly as patients with chronic HIV infection survive to live productive lives. HIV associated cardiomyopathy is among the most common cardiac specific manifestation of chronic HIV infection and was observed in between 6-12% of patients that succumb to AIDS. However, cardiovascular involvement has emerged as more than a pathologic curiosity, but rather as a significant cause of morbidity as individuals live longer, more productive lives with HIV. Increased use of HAART therapy has served to unmask HIV associated predispositions to cardiac involvement. Despite the increased recognition, the risks factors for, the pathogenesis of, and the specific treatments required in HIV associated cardiac disease remain unknown.