PATHOGENESIS OF CARDIAC INJURY IN AIDS

艾滋病心脏损伤的发病机制

• 批准号: 6591338
• 负责人: Richard P Shannon
• 金额: $ 11.11万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6591338
• 关键词: AIDS; Mammalia; bioimaging /biomedical imaging; cardiovascular system; communicable diseases; immunology; inflammation; lymphatic system; ultrasonography; virus

Recent progress in the treatment of AIDS has resulted in prolonged survival and a more protracted course with multiple new clinical manifestations, including an increasing incidence of cardiac dysfunction Despite the clinical recognition, the pathogenesis of HIV cardiomyopathy is unclear, limiting the application of both specific treatments and preventive strategies Simian immunodeficiency virus (SIV) causes an AIDS-like illness in macaques generally characterized by a prolonged clinical latency, a weak neutralizing antibody response, persistent viremia, and tropism for bone marrow-derived cells We have observed physiological evidence of left ventricular dilatation and contractile dysfunction, as well as associated myocardial and vascular pathology in SIV-infected rhesus monkeys which is not seen in uninfected animals This initial characterization of SIV cardiomyopathy constitutes the first description of an experimental model of cardiac dysfunction in AIDS a nd afford s a unique opportunity to investigate its pathogenesis Therefore, using the SIV-infected macaque model of AIDS, we are examining the physiological and cellular basis of AIDS-associated cardiomyopathy

艾滋病治疗的最新进展导致了延长 生存和更旷日持久的课程以及多个新临床 表现形式，包括心脏发病率的增加 功能障碍尽管有临床识别，但HIV的发病机理 心肌病不清楚，限制了两种特定的应用 治疗和预防策略替代免疫缺陷病毒 （SIV）在猕猴中引起类似艾滋病的疾病 通过长时间的临床潜伏期，弱中和抗体 骨髓衍生的反应，持续的病毒血症和潮流 我们已经观察到左心室的生理证据 扩张和收缩功能障碍以及相关 SIV感染的恒河猴中的心肌和血管病理学 在未感染的动物中没有看到SIV的最初特征 心肌病构成了实验的第一个描述 艾滋病中心脏功能障碍的模型，负担得起独特的 因此，使用 SIV感染的杏仁式艾滋病模型，我们正在研究生理 和与艾滋病相关的心肌病的细胞基础