RNAI-BASED GENE SILENCING IN NONHUMAN PRIMATES

非人类灵长类动物中基于 RNAI 的基因沉默

• 批准号: 8172868
• 负责人: Wei-Dong Yao
• 金额: $ 1.81万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172868
• 关键词: Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Gene Silencing; Goals; Grant; Institution; Macaca mulatta; Mediating; Mitotic; Neurobiology; Neurons; Process; Proteins; RNA Interference; Research; Research Personnel; Resources; Source; System; United States National Institutes of Health; Viral; base; nervous system disorder; nonhuman primate; therapeutic development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. RNA interference (RNAi) is an evolutionarily conserved process of sequence-specific post-transcriptional gene silencing. Viral-mediated RNAi allows rapid knockdown of endogenous proteins in post-mitotic cells, including neurons and has great potential in facilitating understanding the neurobiological basis of and therapeutic development against many psychiatric and neurological disorders. The goal of this project is to develop a RNAi-based gene silencing system in rhesus macaque.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 RNA干扰（RNAi）是一种进化上保守的序列特异性转录后基因沉默过程。病毒介导的RNAi允许快速敲低有丝分裂后细胞（包括神经元）中的内源性蛋白，并且在促进理解许多精神和神经障碍的神经生物学基础和治疗开发方面具有巨大潜力。本项目的目标是在恒河猴中建立一个基于RNAi的基因沉默系统。