NOVEL PSD MECHANISMS REGULATING SYNAPTIC DEVELOPMENT, FUNCTION, AND PLASTICITY

调节突触发育、功能和可塑性的新型 PSD 机制

• 批准号: 8357974
• 负责人: Wei-Dong Yao
• 金额: $ 1.38万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357974
• 关键词: Development; Devices; Funding; Grant; Maintenance; National Center for Research Resources; New England; Primates; Principal Investigator; Property; Proteins; Research; Research Infrastructure; Resources; Role; Source; Synapses; United States National Institutes of Health; base; cost; density; novel; postsynaptic; postsynaptic density protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The postsynaptic density (PSD) is generally regarded the unit device that determines the structural and functional properties of a synapse. Among the many proteins that make up the PSD only a limited number has been characterized in great detail. The aim of this project is to identify novel PSD proteins and characterize their roles in synaptic formation, maintenance, and plasticity.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 突触后密度（postsynaptic density，PSD）通常被认为是决定突触结构和功能特性的单位。在组成PSD的许多蛋白质中，只有有限数量的蛋白质被非常详细地表征。该项目的目的是识别新的PSD蛋白，并表征其在突触形成，维持和可塑性中的作用。