DOPAMINERGIC MODULATION OF SYNAPTIC PLASTICITY IN THE PREFRONTAL CORTEX

前额皮质突触可塑性的多巴胺能调节

• 批准号: 8357944
• 负责人: Wei-Dong Yao
• 金额: $ 1.38万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357944
• 关键词: Brain region; Dopamine; Funding; Grant; Hippocampus (Brain); Memory; Molecular; National Center for Research Resources; New England; Prefrontal Cortex; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; Site; Source; Synaptic plasticity; United States National Institutes of Health; base; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Functional activity studies have established prefrontal cortex (PFC) as a critical site for the formation and storage of permanent memories, which likely requires synaptic plasticity in the PFC. Unlike other brain regions, e.g. the hippocampus, the cellular and molecular mechanisms underlying PFC plasticity are poorly understood. This project investigates the role of dopamine in prefrontal synaptic plasticity.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 功能活动的研究已经建立了前额叶皮层（PFC）作为一个重要的网站的形成和存储的永久性记忆，这可能需要在PFC的突触可塑性不同的其他大脑区域，如海马，PFC可塑性的细胞和分子机制知之甚少。本研究探讨多巴胺在前额叶突触可塑性中的作用。