PSD-95 REGULATION OF DOPAMINE RECEPTOR SIGNALING

PSD-95 多巴胺受体信号传导的调节

• 批准号: 8357929
• 负责人: Wei-Dong Yao
• 金额: $ 1.38万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357929
• 关键词: Dendritic Spines; Dopamine Receptor; Funding; Goals; Grant; Head; Mediating; Molecular; National Center for Research Resources; Neurons; New England; Primates; Principal Investigator; Property; Receptor Signaling; Regulation; Research; Research Infrastructure; Resources; Scaffolding Protein; Source; Synapses; United States National Institutes of Health; Vertebral column; base; cost; density; postsynaptic; trafficking

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Dopamine receptors are concentrated in dendritic spines of neurons, including the spine head and the postsynaptic density, where they are thought to control the excitability and synaptic properties of spines. The goal of this project is to investigate the molecular mechanisms mediating the regulation of dopamine receptor localization, trafficking, and function by PSD-95, a prototypic synaptic scaffolding protein within spines.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 多巴胺受体集中在神经元的树突棘中，包括棘头和突触后密度，在那里它们被认为控制棘的兴奋性和突触性质。本项目的目标是研究介导调节多巴胺受体定位，运输和功能的PSD-95，脊髓内的原型突触支架蛋白的分子机制。