WNPRC AGING COLONY RESOURCE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：维持和发展一个专门的资源，为研究有关老龄化。 资源访问分配： WNPRC拥有约108只20岁以上的恒河猴。国家衰老研究所提供部分支持，以维持这些动物用于与正常衰老有关的研究。在2009 -2010财年期间，约15名研究者在与神经内分泌学、热量限制、葡萄糖代谢、血脂异常、卵巢功能障碍、骨密度、骨关节炎、免疫学、干细胞和生殖相关的研究中使用了这些动物。没有拒绝任何请求。 传播： 通过在同行评审期刊上发表文章和出席科学会议，向科学界传播知识。威斯康星州国家灵长类动物研究中心还举行季度研究务虚会，以增加各种服务和资源单位之间的沟通。 进度： 在本报告年度内，约有15名研究者使用了来自老化群体的动物。 我们继续监测殖民地所有动物的健康状况，并对一般饲养地的老龄个体进行评价，以评价其是否适合纳入老龄饲养地。 亮点： 老年恒河猴资源中的动物继续得到良好的医疗照顾。在人口中，目前有一个非常老的人（34岁）。 挑战： 与这种资源相关的主要挑战是保持适当大小的健康群体以满足科学需求。 关注事项： 没有。 培训内容： 提供关于食物摄入量测量、身体成分评估、身体活动监测、认知和运动技能评估以及代谢评估的既定方案的培训。 在过去一年中，在所有这些领域开展了培训。 出版物说明：老龄化资源支持涉及许多部分或全部依赖WNPRC资源的期刊文章。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To maintain and develop a specialized resource for studies related to aging. Allocation of Resource Access: The WNPRC has approximately 108 rhesus monkeys over 20 years of age. Support is provided in part by the National Institute of Aging to maintain these animals for studies relating to normal aging. During FY2009-2010, approximately 15 investigators used these animals in studies related to neuroendocrinology, calorie restriction, glucose metabolism, dyslipidemia, ovarian dysfunction, bone mineral density, osteoarthritis, immunology, stem cells, and reproduction. No request has been denied. Dissemination: Knowledge is disseminated to the scientific community via publications in peer reviewed journals and scientific meeting attendance. The Wisconsin National Primate Research Center also holds quarterly research retreats to create increased communication between the various service and resource units. Progress: During the current reporting year, approximately 15 investigators have utilized animals from the aging colony. We continue to monitor the health and well-being of all animals in the colony and evaluate aging individuals from the general colony to evaluate their appropriateness for inclusion in the aging colony. Highlights: The animals in Aged Rhesus Monkey Resource continue to receive excellent medical attention. Within the population, there is currently one very old (34 years of age) individual. Challenges: The major challenge associated with this resource is maintaining a healthy colony of an appropriate size to meet scientific need. Concerns: None. Training: Training is available on established protocols for food intake measurement, body composition assessment, physical activity monitoring, cognitive and motor skills assessment, and metabolic assessments. Training in all of these areas was carried out during the past year. Publications note: Aging Resource support is involved in numerous journal articles that depend in part or in full on WNPRC resources.