WNPRC AGING COLONY RESOURCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：维护和发展与衰老相关研究的专业资源。 资源访问权限分配： WNPRC大约有108只20岁以上的恒河猴。部分由国家老龄研究所提供支持，以维持这些动物进行与正常衰老有关的研究。在2009-2010财年，大约15名研究人员在神经内分泌学、卡路里限制、葡萄糖代谢、血脂异常、卵巢功能障碍、骨密度、骨关节炎、免疫学、干细胞和生殖等研究中使用了这些动物。没有任何申请被拒绝。 传播： 通过在同行评议的期刊上发表出版物和出席科学会议，向科学界传播知识。威斯康星州国家灵长类研究中心还举行季度研究务虚会，以增加各服务和资源单位之间的沟通。 进度： 在本报告所述年度，大约有15名调查人员利用了来自这个老化殖民地的动物。我们继续监测群体中所有动物的健康和福祉，并评估普通群体中年龄较大的个体，以评估它们是否适合被纳入老年群体。 亮点： 老年恒河猴资源中的动物继续得到极好的医疗护理。在人口中，目前有一名年龄很大(34岁)的人。 挑战： 与这一资源相关的主要挑战是维持一个适当规模的健康群体，以满足科学需求。 关注事项： 没有。 培训： 提供关于食物摄入量测量、身体成分评估、体力活动监测、认知和运动技能评估以及新陈代谢评估的既定方案的培训。所有这些领域的培训都是在过去一年进行的。 出版物注意：老化资源支持涉及许多期刊文章，这些文章部分或全部依赖WNPRC的资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To maintain and develop a specialized resource for studies related to aging. Allocation of Resource Access: The WNPRC has approximately 108 rhesus monkeys over 20 years of age. Support is provided in part by the National Institute of Aging to maintain these animals for studies relating to normal aging. During FY2009-2010, approximately 15 investigators used these animals in studies related to neuroendocrinology, calorie restriction, glucose metabolism, dyslipidemia, ovarian dysfunction, bone mineral density, osteoarthritis, immunology, stem cells, and reproduction. No request has been denied. Dissemination: Knowledge is disseminated to the scientific community via publications in peer reviewed journals and scientific meeting attendance. The Wisconsin National Primate Research Center also holds quarterly research retreats to create increased communication between the various service and resource units. Progress: During the current reporting year, approximately 15 investigators have utilized animals from the aging colony. We continue to monitor the health and well-being of all animals in the colony and evaluate aging individuals from the general colony to evaluate their appropriateness for inclusion in the aging colony. Highlights: The animals in Aged Rhesus Monkey Resource continue to receive excellent medical attention. Within the population, there is currently one very old (34 years of age) individual. Challenges: The major challenge associated with this resource is maintaining a healthy colony of an appropriate size to meet scientific need. Concerns: None. Training: Training is available on established protocols for food intake measurement, body composition assessment, physical activity monitoring, cognitive and motor skills assessment, and metabolic assessments. Training in all of these areas was carried out during the past year. Publications note: Aging Resource support is involved in numerous journal articles that depend in part or in full on WNPRC resources.