Translation analysis of a novel intervention for diet-induced obesity

饮食引起的肥胖的新型干预措施的翻译分析

• 批准号: 9894546
• 负责人: RICKI J COLMAN
• 金额: $ 19.38万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9894546
• 关键词: Adipose tissue; Adult; Age; Age Factors; Aging; Alzheimer' s Disease; American; Amino Acids; Animal Model; Blood; Body Composition; Body Weight decreased; Branched-Chain Amino Acids; Callithrix; Callithrix jacchus jacchus; Calories; Cardiovascular Diseases; Consumption; Data; Development; Diabetes Mellitus; Diet; Diet Modification; Dietary Intervention; Dietary Proteins; Disease; Eating; Elderly; Fatty acid glycerol esters; Female; Future; Goals; Health; Health Promotion; High Fat Diet; High Prevalence; Human; Impairment; Incidence; Insulin Resistance; Intervention; Isoleucine; Lead; Leucine; Longevity; Macronutrients Nutrition; Malignant Neoplasms; Metabolic; Modeling; Molecular; Morbidity - disease rate; Mus; Non-Insulin-Dependent Diabetes Mellitus; Obese Mice; Obesity; Overweight; Pharmacologic Substance; Primates; Protein-Restricted Diet; Proteins; Proteome; Proteomics; Rattus; Research; Risk; Risk Factors; Rodent; Sampling; Skeletal Muscle; Sucrose; Testing; Thinness; Translations; Valine; Work; age group; age related; aged; blood glucose regulation; comparative; dietary control; disorder risk; energy balance; experimental study; feeding; fitness; food surveillance; glycemic control; healthspan; human old age (65+); improved; insight; male; metabolome; metabolomics; mortality; nonhuman primate; novel; novel strategies; obesity risk; preservation; prevent; response; restoration; sugar; western diet

Project Summary Advancing age is associated with an increased risk of type 2 diabetes, which is exacerbated by the high prevalence of obesity in the aged. These disorders are risk factors for age-related diseases associated with significant morbidity and mortality, including cancer, cardiovascular disease, and Alzheimer’s disease. New approaches to maintain glucose homeostasis in the aged are therefore urgently needed. The objective of the proposed study is to test a reduced branched-chain amino acid diet, recently shown in mice to reverse diet induced obesity and insulin resistance, in a small nonhuman primate, the common marmoset. We will also gain insight into the molecular mechanisms induced by reduced dietary branched-chain amino acids through comparative metabolomic and proteomic analysis of blood and skeletal muscle samples from marmosets and from young and aged mice. These studies are urgently needed to understand if manipulation of specific dietary amino acids is a translatable intervention to promote metabolic health and increase healthspan.

项目摘要 年龄的增加与2型糖尿病的风险增加有关，这是由于高血糖而加剧的。 老年人肥胖的流行率。这些疾病是与年龄相关疾病的危险因素， 显著的发病率和死亡率，包括癌症、心血管疾病和阿尔茨海默病。新 因此，迫切需要维持老年人葡萄糖稳态的方法。的目的 一项拟议的研究是测试减少支链氨基酸饮食，最近在小鼠中显示，扭转饮食 诱导肥胖和胰岛素抵抗，在一个小的非人类灵长类动物，普通的绒猴。我们也将获得 深入了解减少膳食支链氨基酸诱导的分子机制， 对来自绒猴的血液和骨骼肌样品进行比较代谢组学和蛋白质组学分析， 年轻和年老的老鼠。这些研究是迫切需要了解，如果操纵特定的饮食 氨基酸是一种可转化的干预措施，以促进代谢健康和增加健康寿命。