RSV to Asthma Cooperative Clinical Ascertainment and Biospecimen Research Core

RSV 与哮喘合作临床确定和生物样本研究核心

• 批准号: 8196536
• 负责人: Tina V Hartert
• 金额: $ 43.39万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8196536
• 关键词: 4 year old; Accident and Emergency department; Acute; Address; Age; Age-Months; Age-Years; Aliquot; Allergic; Allergic Disease; Argentina; Asthma; Blood; Bronchiolitis; Calendar; Caring; Child; Childhood; Childhood Asthma; Chronic; Chronic lung disease; Classification; Clinic; Clinical; Code; DNA; Data; Databases; Demographic Factors; Development; Diagnosis; Disease; Enrollment; Epidemiologist; Etiology; Family; Funding; Genetic; Genotype; Healthcare; Home visitation; Hospitals; House Call; Hypersensitivity; IgE; Immune; Immune response; Immunologist; Infant; Integration Host Factors; International; Intervention; Investigation; Lead; Life; Link; Lower Respiratory Tract Infection; Molecular; Monitor; Names; Nose; Outcome; Outcome Assessment; Phenotype; Physicians; Plasma; Questionnaires; Recording of previous events; Recruitment Activity; Recurrence; Recurrent disease; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Respiratory Syncytial Virus Infections; Respiratory Tract Infections; Respiratory syncytial virus; Risk; Role; Sampling; Scientist; Seasons; Severities; Severity of illness; Specimen; Symptoms; Telephone; Time; United States National Institutes of Health; Upper Respiratory Infections; Urine; Viral; Virus; Virus Diseases; Visit; Vulnerable Populations; Wheezing; Work; acronyms; atopy; base; cohort; comparison group; data management; early childhood; experience; follow-up; human DNA; improved; infancy; lung injury; pathogen; pediatrician; prospective; repository; respiratory; viral detection; virus genetics

CORE B: The purpose of this core is to establish and administer a prospective cohort, clinical database, and biospecimen repository that will enable research on the role of RSV in atopic and chronic lung disease inception. The core will support scientific projects that focus on host factors (Project 1), viral factors (Project 2), and mechanisms through which target interventions may work (Project 3). This core will prospectively enroll and follow 2000 term otherwise healthy infants who will be < 6 months of age during winter virus season through age 3-4 years, at which time recurrent childhood wheeze and allergic sensitization will be defined - named the ReSPIRA cohort (Respiratory Study for Protection of Infants from RSV to Asthma). The core will provide detailed clinical information and biospecimens on a tightly phenotyped group of infants with a high likelihood of developing asthma, and thus allows the projects which this core serves to identify host genetic, viral genetic, cellular, immune, and molecular determinants of recurrent wheezing, early childhood asthma and atopy following infant RSV infection. The first two years of the clinical core will focus on enrollment, and the 3 subsequent years will focus on cohort follow-up and delivery of data and biospecimens to co-investigators, whose projects will address research questions related to RSV illness and early childhood asthma. Our specific aims are to: (1) Create the ReSPIRA cohort; (2) Clinically characterize (phenotype) the infant cohort in Argentina with regards to RSV infection status, host response, and lung injury during infancy, on the outcomes of recurrent childhood wheezing, asthma, and atopy; and (3) Establish and maintain a biospecimen repository and distribute its' resources to conduct studies on the mechanisms through which RSV infection may lead to recurrent wheezing and asthma development. This core supports the overall Center by centralizing resources on cohort inception, detailed classification of RSV infection/exposure, outcomes assessments, data management and administration, to support the study of the role of infant RSV illness on later childhood atopy and asthma outcomes. As bronchiolitis and asthma are the most common, serious, acute and chronic conditions of infancy and childhood, respectively, and are diseases that disproportionately burden vulnerable populations, this core and supported projects will have major, long-lasting impact by improving our understanding of the role of, and the mechanisms through which RSV contributes to later childhood outcomes.

核心B：该核心的目的是建立和管理前瞻性队列、临床数据库， 生物标本库，这将使研究RSV在特应性和慢性肺部疾病中的作用成为可能 植入核心将支持科学项目，重点是宿主因素（项目1），病毒因素（项目2）， （2），以及目标干预措施可能发挥作用的机制（项目3）。这一核心将前瞻性地 招募并随访2000名在冬季病毒感染期间年龄<6个月的足月健康婴儿 季节通过年龄3 - 4岁，在这个时候，反复发作的儿童喘息和过敏性致敏将是 ReSPIRA队列（Respiratory Study for Protection of Infants from RSV to Asthma）。 核心将提供详细的临床信息和生物标本的一个严格的表型组的婴儿 患哮喘的可能性很高，因此允许该核心服务的项目识别 反复喘息的宿主遗传、病毒遗传、细胞、免疫和分子决定因素， 儿童哮喘和婴儿RSV感染后的特应性。前两年的临床核心将集中在 入组，随后3年将重点关注队列随访和数据交付， 生物标本，以共同研究者，其项目将解决与RSV疾病有关的研究问题， 儿童早期哮喘我们的具体目标是：（1）创建ReSPIRA队列;（2）临床表征 （表型）阿根廷婴儿队列中RSV感染状态、宿主应答和肺 婴儿期损伤，对儿童期反复喘息、哮喘和特应性的结果;和（3）建立 并维持一个生物标本库，并分配其资源进行机制研究 RSV感染可通过该途径导致反复喘息和哮喘发展。 该核心通过集中队列启动、详细分类 RSV感染/暴露、结局评估、数据管理和给药，以支持研究 婴儿RSV疾病对儿童后期特应性和哮喘结局的作用。细支气管炎和哮喘 分别是婴儿期和儿童期最常见、最严重、最急性和最慢性的疾病， 这些疾病给弱势群体造成了不成比例的负担，这一核心和支持项目将 通过提高我们对以下方面的作用和机制的认识， RSV有助于儿童后期的结果。