RSV to Asthma Cooperative Clinical Ascertainment and Biospecimen Research Core

RSV 与哮喘合作临床确定和生物样本研究核心

• 批准号: 8196536
• 负责人: Tina V Hartert
• 金额: $ 43.39万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8196536
• 关键词: 4 year old; Accident and Emergency department; Acute; Address; Age; Age-Months; Age-Years; Aliquot; Allergic; Allergic Disease; Argentina; Asthma; Blood; Bronchiolitis; Calendar; Caring; Child; Childhood; Childhood Asthma; Chronic; Chronic lung disease; Classification; Clinic; Clinical; Code; DNA; Data; Databases; Demographic Factors; Development; Diagnosis; Disease; Enrollment; Epidemiologist; Etiology; Family; Funding; Genetic; Genotype; Healthcare; Home visitation; Hospitals; House Call; Hypersensitivity; IgE; Immune; Immune response; Immunologist; Infant; Integration Host Factors; International; Intervention; Investigation; Lead; Life; Link; Lower Respiratory Tract Infection; Molecular; Monitor; Names; Nose; Outcome; Outcome Assessment; Phenotype; Physicians; Plasma; Questionnaires; Recording of previous events; Recruitment Activity; Recurrence; Recurrent disease; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Respiratory Syncytial Virus Infections; Respiratory Tract Infections; Respiratory syncytial virus; Risk; Role; Sampling; Scientist; Seasons; Severities; Severity of illness; Specimen; Symptoms; Telephone; Time; United States National Institutes of Health; Upper Respiratory Infections; Urine; Viral; Virus; Virus Diseases; Visit; Vulnerable Populations; Wheezing; Work; acronyms; atopy; base; cohort; comparison group; data management; early childhood; experience; follow-up; human DNA; improved; infancy; lung injury; pathogen; pediatrician; prospective; repository; respiratory; viral detection; virus genetics

CORE B: The purpose of this core is to establish and administer a prospective cohort, clinical database, and biospecimen repository that will enable research on the role of RSV in atopic and chronic lung disease inception. The core will support scientific projects that focus on host factors (Project 1), viral factors (Project 2), and mechanisms through which target interventions may work (Project 3). This core will prospectively enroll and follow 2000 term otherwise healthy infants who will be < 6 months of age during winter virus season through age 3-4 years, at which time recurrent childhood wheeze and allergic sensitization will be defined - named the ReSPIRA cohort (Respiratory Study for Protection of Infants from RSV to Asthma). The core will provide detailed clinical information and biospecimens on a tightly phenotyped group of infants with a high likelihood of developing asthma, and thus allows the projects which this core serves to identify host genetic, viral genetic, cellular, immune, and molecular determinants of recurrent wheezing, early childhood asthma and atopy following infant RSV infection. The first two years of the clinical core will focus on enrollment, and the 3 subsequent years will focus on cohort follow-up and delivery of data and biospecimens to co-investigators, whose projects will address research questions related to RSV illness and early childhood asthma. Our specific aims are to: (1) Create the ReSPIRA cohort; (2) Clinically characterize (phenotype) the infant cohort in Argentina with regards to RSV infection status, host response, and lung injury during infancy, on the outcomes of recurrent childhood wheezing, asthma, and atopy; and (3) Establish and maintain a biospecimen repository and distribute its' resources to conduct studies on the mechanisms through which RSV infection may lead to recurrent wheezing and asthma development. This core supports the overall Center by centralizing resources on cohort inception, detailed classification of RSV infection/exposure, outcomes assessments, data management and administration, to support the study of the role of infant RSV illness on later childhood atopy and asthma outcomes. As bronchiolitis and asthma are the most common, serious, acute and chronic conditions of infancy and childhood, respectively, and are diseases that disproportionately burden vulnerable populations, this core and supported projects will have major, long-lasting impact by improving our understanding of the role of, and the mechanisms through which RSV contributes to later childhood outcomes.

核心B：这个核心的目的是建立和管理一个预期的队列、临床数据库和 将有助于研究呼吸道合胞病毒在特应性和慢性肺部疾病中的作用的生物谱系资料库 盗梦空间。核心将支持侧重于宿主因素(项目1)、病毒因素(项目)的科学项目 2)，以及目标干预可能发挥作用的机制(项目3)。这一核心将前瞻性地 登记和跟踪2000个足月，否则健康的婴儿将在冬季病毒期间&lt；6个月大 季节到3-4岁，此时儿童反复喘息和过敏反应 定义--命名为呼吸队列(保护婴儿从呼吸道合胞病毒感染到哮喘的呼吸研究)。 核心将提供详细的临床信息和对一组严格表型的婴儿进行生物显微镜检查。 患哮喘的可能性很高，因此允许这个核心用于确定的项目 反复喘息的宿主遗传、病毒遗传、细胞、免疫和分子决定因素，早期 婴幼儿呼吸道合胞病毒感染后的儿童哮喘和特应性。临床核心的头两年将专注于 在招生方面，随后的3年将侧重于队列跟踪和数据交付以及 合作研究人员，他们的项目将解决与RSV疾病相关的研究问题 儿童早期哮喘。我们的具体目标是：(1)创建呼吸队列；(2)临床特征 (表型)阿根廷与呼吸道合胞病毒感染状态、宿主反应和肺部相关的婴儿队列 婴儿期损伤对反复发作的儿童喘息、哮喘和特应性疾病的影响；以及(3)确定 并维持一个生物菌素储存库并分配其资源以进行机制研究 通过呼吸道合胞病毒感染可能导致反复喘息和哮喘的发展。 这一核心通过将资源集中在队列启动、详细分类 RSV感染/暴露、结果评估、数据管理和行政，以支持这项研究 婴儿呼吸道合胞病毒疾病对儿童后期特应性和哮喘结局的作用。如毛细支气管炎和哮喘 分别是婴儿期和儿童期最常见、最严重、最急性和最慢性的疾病，它们是 疾病给脆弱人群带来不成比例的负担，这一核心和得到支持的项目将 通过提高我们对……的作用和机制的了解，产生重大、持久的影响 呼吸道合胞病毒对儿童以后的结局有贡献。