Clinical Ascertainment, Biospecimen Acquisition, Data Management and Analysis Research Core

核心B摘要-临床确定、保留和生物样品获取研究核心 这个核心的目的是发展和支持两个人类出生队列，作为 研究人群以解决有关呼吸道合胞病毒(RSV)在 儿童呼吸道发病率和哮喘通过关注儿童呼吸道疾病相互作用途径的科学项目 宿主和病毒对哮喘发展的影响(项目1)，以及可能改变免疫和呼吸道的干预措施 呼吸道合胞病毒可能导致哮喘的上皮细胞发育(项目2)。这种临床上的确定， 留存和生物样本获取和管理研究的核心将服务于管理这两项人类研究 人口：婴儿对呼吸道合胞病毒暴露后肺部感染和哮喘的易感性(INSPIRE)和 儿童过敏和新生儿环境(独木舟)，并管理由此产生的关键生物群落和 数据。数据采集将包括仔细的表型鉴定、RSV暴露评估、生理测试、鼻腔 收集呼吸道上皮细胞(NAEC)、鼻刷、血和外周血单核细胞 (PBMC)，以及项目1和2的DNA。 这一核心以范德比尔特的丰富基础设施为中心，并围绕着敬业的儿科 和产科诊所进行临床研究。这包括对招募、登记和 保留出生队列、纵向随访和生物样本采集的实验室组成部分 和处理中。这个核心汇集了一个由流行病学家、病毒学家、 在队列保留方面经验丰富的免疫学家、遗传学家、生物统计学家和研究人员，以及 生物谱采集，并将向分析核心C提供数据和生物谱，数据将在那里 将进行加工和生物统计分析。这一核心被构建为两个目标，每个目标 支持两个队列中的一个。第一个目标是协助和监督 建立了INSPIRE出生队列、生物制品收集，包括项目1和2的NAEC。第二个是 便利和监督新的独木舟出生队列的招募、登记和纵向后续行动，以及 生物菌素收集，包括项目1和2的NAECs。

CORE B ABSTRACT - Clinical Ascertainment, Retention and Biospecimen Acquisition Research Core The purpose of this core is to develop and support the two human birth cohorts which serve as the study populations to address fundamental questions about the role of respiratory syncytial virus (RSV) on childhood respiratory morbidity and asthma through scientific projects that focus on interactive pathways of the host and virus on asthma development (Project 1), and interventions that may modify immune and airway epithelial cell development through which RSV may cause asthma (Project 2). This clinical ascertainment, retention and biosample acquisition and management research core will serve to manage the two human study populations: Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure (INSPIRE) and Childhood Allergy and the Neonatal Environment (CANOE), and manage the resultant key biospecimens and data. Data acquisition will include careful phenotyping, RSV exposure assessment, physiologic testing, nasal airway epithelial cell (NAEC) collection, nasal brushings, blood and peripheral blood mononuclear cells (PBMCs), and DNA for Projects 1 and 2. This core is centered around the rich infrastructure at Vanderbilt and surrounding engaged pediatric and obstetrical clinics to conduct the clinical studies. This includes support for the recruitment, enrollment and retention of the birth cohorts, longitudinal follow-up, and the laboratory components of the biosample collection and processing. This core assembles a complementary research team of epidemiologists, virologists, immunologists, geneticists, biostatisticians, and research personnel experienced in cohort retention, and biospecimen acquisition and will provide the data and biospecimens to analytic Core C where data will be processed and biostatistical analyses will be conducted. This core is structured as two aims with each supporting one of the two cohorts. The first is to facilitate and oversee the longitudinal follow-up of the established INSPIRE birth cohort, biospecimen collection, including NAECs for Projects 1 and 2. The second is to facilitate and oversee recruitment, enrollment and longitudinal follow-up of the new CANOE birth cohort, and biospecimen collection, including NAECs for Projects 1 and 2.