ECHO Renewal for the CANOE Study Cohort

CANOE 研究队列的 ECHO 更新

• 批准号: 10745082
• 负责人: Tina V Hartert
• 金额: $ 132.05万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745082
• 关键词: 2 year old; Address; Age; Asthma; Biological Process; Biological Specimen Banks; Birth; Black Populations; Bronchiolitis; COVID-19 pandemic; Child; Child Health; Childhood; Childhood Acute Lymphocytic Leukemia; Childhood Asthma; Cohort Studies; Collection; Communities; Conceptions; Data; Data Element; Development; Diagnosis; Disease; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Epithelial Cells; Funding; Goals; Hispanic Populations; Hypersensitivity; Incidence; Individual; Infant; Infection; Infrastructure; Intervention; Licensure; Life; Medical History; Mentors; Modification; Monoclonal Antibodies; Neonatal; Nose; Outcome; Participant; Population; Predisposition; Pregnant Women; Prevention; Prevention strategy; Preventive; Primary Prevention; Protocols documentation; Public Health; Publications; Recommendation; Recurrence; Research; Research Personnel; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus Vaccines; Respiratory syncytial virus; Risk; Rural Community; Sampling; Severities; Southeastern United States; Testing; Urban Community; Vaccines; Wheezing; Work; age related; airway epithelium; asthma prevention; chronic respiratory disease; cohort; cost-effectiveness evaluation; design; disorder prevention; diversity and inclusion; early life exposure; ethnic diversity; expectation; follow-up; infancy; infant infection; innovation; interest; low and middle-income countries; middle childhood; multi-racial; novel; pandemic disease; pandemic impact; policy implication; pregnant; prevent; public health intervention; pulmonary function; racial diversity; recruit; resilience factor; respiratory microbiome; retention rate; vaccine acceptance

ABSTRACT The overarching goals of this application are to: 1) maintain retention of children in the Vanderbilt CANOE birth cohort with emphasis on diversity and implementation of the ECHO Cohort Protocol with high fidelity and conduct new enrollment, and 2) address key questions in the field about one of the most common and modifiable early life environmental exposures consistently associated with significantly increased asthma risk, respiratory syncytial virus (RSV) infection, delineating the severity-dependent and age-dependent effects of RSV infection on asthma risk. This innovative project has significant public health impact, as establishing the age- and severity-dependent relationship between RSV and asthma is the first and most important step in disease primary prevention. We propose to address key unanswered questions in the field: the severity- and age-dependent association of RSV and asthma, and the impact of infection on lung function. In addition, we will explore the broad impact of the SARS-CoV-2 pandemic on asthma incidence and control in an exploratory aim, which may provide support for multi-faceted environmental modifications in asthma prevention and control, and data to inform the potential impact of broad public health interventions. The birth cohort that this application supports is the Vanderbilt CANOE (Childhood Allergy and the NeOnatal Environment) study. CANOE is a birth cohort designed to identify and understand how environmental factors modify the development of the airway epithelium. The study includes the unique longitudinal sampling of the child airway throughout the first year of life, and annually. The Vanderbilt CANOE study has unique early life exposure and outcomes ascertainment, including surveillance for RSV and a novel biospecimen repository of nasal airway epithelial cells. The CANOE cohort also has important information for longitudinal development of the airway microbiome and the airway epithelium. The proposed research is innovative and timely given the anticipated licensure of multiple RSV prevention products in the coming year (maternal vaccines and long- acting monoclonal antibodies for infants). The proposed work represents a novel, multi-faceted approach to identifying and understanding the influence of severity of RSV infection and age of RSV infection on asthma risk and lung function. The answers to these questions will be critical to developing prevention strategies and informing public health expectations for RSV non-pharmaceutical preventive strategies and evaluating potential long-term value-added benefits of vaccines in preventing lifelong chronic respiratory disease. These data may not only bolster RSV vaccine acceptability and uptake in the US, but will almost certainly be useful in evaluating the cost-effectiveness of RSV prevention strategies in low and middle income countries.

摘要 此应用程序的首要目标是：1)在范德比尔特独木舟出生期间保留儿童 强调多样性和高保真的回声队列协议的实施 进行新登记，以及2)解决有关以下最常见和最常见的问题之一的关键问题 可改变的早期生活环境暴露与显著增加的哮喘风险一致相关， 呼吸道合胞病毒(RSV)感染，描绘了严重依赖和年龄依赖的影响 呼吸道合胞病毒感染对哮喘风险的影响。这一创新项目具有重大的公共卫生影响，因为建立 RSV和哮喘之间的年龄和严重程度依赖关系是第一步也是最重要的一步 疾病一级预防。我们建议解决该领域尚未回答的关键问题：严重性-以及 呼吸道合胞病毒与哮喘的年龄相关性，以及感染对肺功能的影响。此外，我们 将探索性地探讨SARS-CoV-2大流行对哮喘发病和控制的广泛影响 AIM，可为哮喘预防和治疗中的多方面环境改造提供支持 控制和数据，以告知广泛的公共卫生干预的潜在影响。 这个应用程序支持的出生队列是Vanderbilt独木舟(儿童过敏和新生儿 环境)研究。独木舟是一个出生队列，旨在识别和理解环境因素如何 改善呼吸道上皮细胞的发育。这项研究包括独特的纵向抽样 在生命的第一年，每年都有儿童呼吸道疾病。范德比尔特独木舟研究具有独特的早期生命 暴露和结果确定，包括监测呼吸道合胞病毒和一种新的生物检验库 鼻腔呼吸道上皮细胞。独木舟队列也有重要的信息，以纵向发展 呼吸道微生物群和呼吸道上皮细胞。建议的研究是创新的和及时的，因为 预计在来年获得多种RSV预防产品的许可(产妇疫苗和长期 婴儿用的代理单抗)。拟议的工作代表了一种新颖的、多方面的方法来 识别和了解呼吸道合胞病毒感染严重程度和年龄对哮喘的影响 风险和肺功能。这些问题的答案对于制定预防战略和 告知公众对RSV非药物预防策略的期望和评估潜力 疫苗在预防终生慢性呼吸道疾病方面的长期增值效益。这些数据可能 不仅提高了RSV疫苗在美国的接受度和接受度，而且几乎肯定会对 评估低收入和中等收入国家RSV预防战略的成本效益。