Clinical Ascertainment, Biospecimen Acquisition, Data Management and Analysis Research Core

临床确定、生物样本采集、数据管理和分析研究核心

• 批准号: 10262868
• 负责人: Tina V Hartert
• 金额: $ 42.64万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-04 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10262868
• 关键词: 10 year old; 8 year old; Address; Age; Allergic Disease; Asthma; Biometry; Birth; Blood; Child; Childhood; Childhood Asthma; Clinic; Clinical; Clinical Management; Clinical Research; Collection; DNA; Data; Data Analyses; Data Collection; Development; Discipline of obstetrics; Disease Outcome; Enrollment; Ensure; Environment; Epidemiologist; Epithelial Cells; Funding; Human; Hypersensitivity; Immune; Immunologist; Infant; Infection; Infrastructure; Intervention; Laboratories; Lung infections; Methodology; Neonatal; Nose; Pathway interactions; Peripheral Blood Mononuclear Cell; Persons; Phenotype; Physiological; Predisposition; Pregnancy; Process; Randomized; Research; Research Personnel; Resources; Respiratory Syncytial Virus Infections; Respiratory syncytial virus; Role; Sampling; Site; Specimen; Structure; Techniques; Testing; United States National Institutes of Health; Viral; Virus; Visit; Woman; acronyms; airway epithelium; clinical phenotype; cohort; data acquisition; data management; design; epidemiology study; experience; follow-up; human population study; infancy; multidimensional data; novel; recruit; respiratory morbidity; study population; synergism

CORE B ABSTRACT - Clinical Ascertainment, Retention and Biospecimen Acquisition Research Core The purpose of this core is to develop and support the two human birth cohorts which serve as the study populations to address fundamental questions about the role of respiratory syncytial virus (RSV) on childhood respiratory morbidity and asthma through scientific projects that focus on interactive pathways of the host and virus on asthma development (Project 1), and interventions that may modify immune and airway epithelial cell development through which RSV may cause asthma (Project 2). This clinical ascertainment, retention and biosample acquisition and management research core will serve to manage the two human study populations: Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure (INSPIRE) and Childhood Allergy and the Neonatal Environment (CANOE), and manage the resultant key biospecimens and data. Data acquisition will include careful phenotyping, RSV exposure assessment, physiologic testing, nasal airway epithelial cell (NAEC) collection, nasal brushings, blood and peripheral blood mononuclear cells (PBMCs), and DNA for Projects 1 and 2. This core is centered around the rich infrastructure at Vanderbilt and surrounding engaged pediatric and obstetrical clinics to conduct the clinical studies. This includes support for the recruitment, enrollment and retention of the birth cohorts, longitudinal follow-up, and the laboratory components of the biosample collection and processing. This core assembles a complementary research team of epidemiologists, virologists, immunologists, geneticists, biostatisticians, and research personnel experienced in cohort retention, and biospecimen acquisition and will provide the data and biospecimens to analytic Core C where data will be processed and biostatistical analyses will be conducted. This core is structured as two aims with each supporting one of the two cohorts. The first is to facilitate and oversee the longitudinal follow-up of the established INSPIRE birth cohort, biospecimen collection, including NAECs for Projects 1 and 2. The second is to facilitate and oversee recruitment, enrollment and longitudinal follow-up of the new CANOE birth cohort, and biospecimen collection, including NAECs for Projects 1 and 2.

核心B摘要-临床确认、保留和生物样本采集研究核心 该核心的目的是发展和支持两个人类出生队列， 研究人群，以解决有关呼吸道合胞病毒（RSV）在 儿童呼吸道疾病和哮喘通过科学项目，重点是互动的途径， 宿主和病毒对哮喘发展的影响（项目1），以及可能改变免疫和气道的干预措施 上皮细胞发育，RSV可通过上皮细胞发育引起哮喘（项目2）。临床确认， 保留和生物样本采集和管理研究核心将用于管理两项人类研究 人群：RSV暴露后婴儿对肺部感染和哮喘的易感性（INSPIRE）和 儿童过敏和新生儿环境（CANOE），并管理由此产生的关键生物标本， 数据数据采集将包括仔细的表型分型、RSV暴露评估、生理学测试、鼻内窥镜检查、呼吸道感染、呼吸道感染和呼吸道感染。 气道上皮细胞（NAEC）采集、鼻刷、血液和外周血单核细胞 （PBMC），以及项目1和2的DNA。 该核心以范德比尔特丰富的基础设施和周围参与儿科为中心 和产科诊所进行临床研究。这包括对招聘、注册和 保留出生队列、纵向随访和生物样本采集的实验室组成部分 和处理这个核心汇集了一个由流行病学家、病毒学家、 免疫学家、遗传学家、生物统计学家和具有队列保留经验的研究人员，以及 生物标本采集，并将数据和生物标本提供给分析核心C， 将进行处理和生物统计分析。这个核心由两个目标组成，每个目标 支持两支队伍中的一支第一是促进和监督《公约》的纵向后续行动， 建立INSPIRE出生队列，收集生物标本，包括项目1和2的NAEC。二是 促进和监督新CANOE出生队列的招募、入组和纵向随访，以及 生物标本采集，包括项目1和2的NAEC。