课题基金 / 基金详情

Macque

Macque
马克
批准号:
8198168
负责人:
Francois J Villinger
金额:
$119.41万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-07-07 至 2016-06-30

项目摘要

项目成果

Francois J Villinger的其他基金

相似基金

相关文献

中文摘要
翻译
本项目的长期目标是开发针对粘膜SIV(和HIV)的疫苗策略
英文摘要
The long-range goal of this Program Project is to develop vaccine strategies against mucosal SIV (and HIV in the future) transmission, with a special focus on identifying local and systemic mechanisms leading to protecfive B cell development and antibody production. The objectives for the Primate Core are to provide the experimental animals and support services needed to facilitate the efficient completion of the aims outlined in Project 1, 2, 3 and 4. This will include the provision of retrovirus-free adult female rhesus macaques from the Yerkes rhesus macaque breeding colonies; immunizafions using the various immunizafion platforms (Projects 1 and 2) sample collections (for all projects) and repeated low dose vaginal challenges with SIVsmE660. The Primate Core tasks also include daily monitoring ofthe experimental animals; periodic physical examinafions with blood collecfions for immunologic and virologic evaluations and procurement/shipment of samples to the Program Project invesfigators; the performance of CBCs and laboratory analyses as needed; Perform euthanasia with sample collecfion and processing for Projects 3 and 4; and the performance of a basic gross and histologic necropsy evaluations of all experimental animals that die or are sacrificed during the course of this study. Provision of these resources and support services will facilitate the development and testing of novel AIDS vaccine concepts proposed in this Program Project. The Primate Core will play a key role in the development of a vaccine to prevent mucosal transmission and pathogenicity of SIV and HIV and the determination Of correlates of such protection. Vaccine efficacy will be evaluated by its ability to 1) prevent acquisition of infecfion (sterilizing immunity) or 2) significant control of viremia post-challenge and preservation of protective immune responses.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Expansion of Macaque Breeding runs at the New Iberia Research Center
  • 批准号:
    10761902
  • 项目类别:
  • 资助金额:
    $399.91万
  • 财政年份:
    2023
  • 负责人:
    Francois J Villinger
  • 依托单位:
Core D: Nonhuman Primates
  • 批准号:
    10425029
  • 项目类别:
  • 资助金额:
    $152.77万
  • 财政年份:
    2022
  • 负责人:
    Francois J Villinger
  • 依托单位:
Nonhuman Primate Core
  • 批准号:
    10460075
  • 项目类别:
  • 资助金额:
    $53.24万
  • 财政年份:
    2022
  • 负责人:
    Francois J Villinger
  • 依托单位:
Nonhuman Primate Core
  • 批准号:
    10666570
  • 项目类别:
  • 资助金额:
    $51.8万
  • 财政年份:
    2022
  • 负责人:
    Francois J Villinger
  • 依托单位:
海外基金