Positive Emotional Processing: Exploring Novel Treatment Targets in Social Phobia

积极的情绪处理:探索社交恐惧症的新治疗目标

基本信息

  • 批准号:
    8046838
  • 负责人:
  • 金额:
    $ 9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-01-01 至 2012-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The current proposal is for a NIMH Pathway to Independence Award (K99/R00) designed to strengthen and expand the candidate's expertise in translational research in the area of anxiety disorders. Career Development Plan: The candidate possesses a strong background in basic experimental psychopathology and treatment outcome research in anxiety. A consistent theme running throughout the candidate's research is the application of basic concepts and experimental procedures in social cognition to study the factors hypothesized to bias the processing and assimilation of positive social information in individuals with generalized social anxiety disorder (GSAD). The goal of these experimental studies is to provide novel insights into ways of addressing treatment refractory cases with GSAD. His long-term career objectives are to remain in academia as a treatment-oriented clinical scientist with the requisite skills that will ensure his success as a productive member of an interdisciplinary research team. The candidate recognizes the importance of expanding his existing skill set, particularly in information processing and neurobiological approaches to examine basic mechanisms and treatment response in anxiety. Accordingly, the career development plan will take advantage of cross-site mentorship from leading experts at the vanguard of research studying the cognitive-affective (Dr. Nader Amir, San Diego State University) and neurobiological bases of pathological anxiety and fear (Dr. Murray Stein, University of California, San Diego; Dr. Martin Paulus, UCSD). These researchers direct active programs of translational clinical research that will provide the candidate with rich hands-on training in the context of ongoing projects. The candidate will also complete formal coursework and intensive seminars in neuroimaging, biostatistics, and the ethical conduct of research. Environment: The long-standing and highly successful collaborative history between the SDSU Department of Psychology and UCSD Department of Psychiatry provides the strong and well-established institutional infrastructure that will promote the successful execution of the proposed training plan. The candidate will benefit from the unique opportunity to witness the successful merging of a traditional psychology department with a research-oriented psychiatry department, a context that will provide an in vivo opportunitiy to function as part of a trans-disciplinary research team. The exceptional academic reputation, available mentorship and consultation of internationally recognized leaders in the field, and collaborative interdisciplinary environment of SDSU and UCSD unite to create a training environment that is ideally suited to promote the candidate's career development and transition to independence. Research plan: GSAD is a common and debilitating condition, marked by significant impairments in social relationship functioning and an overall diminished quality of life (e.g., Alden & Taylor, 2004, 2010; Stein & Stein, 2008). Contemporary treatment approaches for anxiety disorders, including GSAD, are grounded in fear-based models of extinction learning (see Craske et al., 2008; McNally, 2007). As a result, these treatments have been removed from research pointing to a dysregulation of basic regulatory systems involved in the processing of positive social and emotional information in GSAD (see Kashdan, 2007 for a review). Indeed, despite the efficacy of existing treatments in reducing symptoms of social anxiety and avoidance (e.g., Hofmann & Smits, 2008; Rodebaugh et al., 2004; Stein & Stein, 2008), many individuals with GSAD remain residually symptomatic and continue to experience significant disruptions in domains of positive social functioning following treatment (Eng et al., 2005). These deficiencies are notable given that positive social and emotional experiences are consistently shown to have a beneficial impact on psychological and physical health outcomes (e.g., Folkman & Moskowitz, 2000; Lyubomirsky et al., 2005). In contrast, limited social ties and social isolation are associated with increased morbidity and risk of mortality (e.g., Cacioppo et al., 2003; House et al., 1988), which positions GSAD as a significant public health concern. Thus, to bridge the gap between basic findings in social cognition and affective neuroscience and existing treatments for SAD, the candidate proposes a series of studies designed to elucidate the cognitive, affective, and neurobiological substrates of aberrant positive emotional responsiveness in GSAD. The goal of these studies is to identify novel targets for the development of experimental procedures designed to modify deficits in positive social emotional processing in GSAD (R phase). The long-term goal of this research is to develop interventions that can augment existing treatment approaches in the service of enhancing treatment response and positive social functioning in refractory GSAD patients. PUBLIC HEALTH RELEVANCE: Social anxiety disorder (SAD) is a common and debilitating condition, marked by significant impairments in social functioning and an overall diminished quality of life. Although existing treatments are efficacious in reducing symptoms of social anxiety and avoidance, individuals with SAD continue to report significant disruptions in social relationship functioning following treatment. Thus, the current proposal aims to address these issues by evaluating the effects of experimental procedures designed to enhance positive social and emotional functioning in SAD.
描述(由申请人提供):目前的建议是设立NIMH独立之路奖(K99/R00),旨在加强和扩大候选人在焦虑症领域的翻译研究方面的专业知识。职业发展计划:应聘者在焦虑症的基础实验精神病理学和治疗结果研究方面有很强的背景。贯穿候选人研究始终的一个主题是,应用社会认知中的基本概念和实验程序,研究广泛性社交焦虑症(GSAD)患者对积极社会信息的加工和同化的假设因素。这些实验研究的目的是为解决GSAD难治性病例的治疗方法提供新的见解。他的长期职业目标是作为一名以治疗为导向的临床科学家留在学术界,拥有必要的技能,以确保他作为跨学科研究团队中富有成效的成员取得成功。候选人认识到扩大现有技能集的重要性,特别是在信息处理和神经生物学方法方面,以检查焦虑的基本机制和治疗反应。因此,职业发展计划将利用研究认知-情感(圣地亚哥州立大学的Nader Amir博士)和病理性焦虑和恐惧的神经生物学基础(加州大学圣地亚哥分校的Murray Stein博士;加州大学圣迭戈分校的Martin Paulus博士)研究前沿研究的领先专家的跨站点指导。这些研究人员指导积极的转化性临床研究计划,在正在进行的项目背景下为应聘者提供丰富的动手培训。候选人还将完成神经成像、生物统计学和研究伦理方面的正式课程和密集研讨会。环境:圣地亚哥州立大学心理学系和加州大学圣迭戈分校精神病学系之间长期成功的合作历史提供了强大和成熟的机构基础设施,将促进拟议培训计划的成功执行。应聘者将从见证传统心理学系与研究型精神病学系成功合并的独特机会中受益,这一背景将提供体内机会,成为跨学科研究团队的一部分。SDSU和UCSD出类拔萃的学术声誉、该领域国际公认的领导者提供的指导和咨询,以及SDSU和UCSD的跨学科协作环境相结合,创造了一个非常适合促进候选人职业发展和向独立过渡的培训环境。研究计划:GSAD是一种常见的衰弱疾病,其特点是社会关系功能严重受损,生活质量总体下降(例如,Alden&Taylor,2004,2010;Stein&Stein,2008)。当代治疗焦虑症的方法,包括GSAD,是以恐惧为基础的消亡学习模式(见Craske等人,2008;McNally,2007)。因此,这些治疗方法已经从研究中删除,这些研究指出GSAD涉及积极的社会和情绪信息处理的基本调控系统失调(参见Kashdan,2007年的综述)。事实上,尽管现有治疗方法在减少社交焦虑和回避症状方面有效(例如,Hofmann&Smitts,2008;Rodebaugh等人,2004;Stein&Stein,2008),但许多GSAD患者仍然存在残余症状,并在治疗后继续在积极社会功能领域出现显著障碍(Eng等人,2005年)。这些缺陷是值得注意的,因为积极的社会和情感体验一直被证明对心理和身体健康结果有有益的影响(例如,Folkman&Moskowitz,2000;Lyuomirsky等人,2005)。相比之下,有限的社会联系和社会孤立与发病率和死亡风险的增加有关(例如,Ccioppo等人,2003年;House等人,1988年),这使GSAD成为一个重大的公共卫生问题。因此,为了弥合社会认知和情感神经科学的基本发现与SAD现有治疗方法之间的差距,候选人提出了一系列研究,旨在阐明GSAD异常积极情绪反应的认知、情感和神经生物学基础。这些研究的目标是确定新的目标,用于开发实验程序,旨在修改GSAD(R阶段)中积极社交情绪加工的缺陷。这项研究的长期目标是开发能够加强现有治疗方法的干预措施,以增强难治性GSAD患者的治疗反应和积极的社会功能。 与公共卫生相关:社交焦虑症(SAD)是一种常见的、令人衰弱的疾病,其特征是社交功能严重受损,生活质量总体下降。虽然现有的治疗方法在减少社交焦虑和回避症状方面是有效的,但SAD患者在治疗后继续报告社会关系功能严重中断。因此,目前的提案旨在通过评估旨在增强SAD患者积极社会和情绪功能的实验程序的效果来解决这些问题。

项目成果

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Charles Taylor其他文献

Charles Taylor的其他文献

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{{ truncateString('Charles Taylor', 18)}}的其他基金

Novel Behavioral Intervention to Target Social Reward Sensitivity and Attachment
针对社会奖励敏感性和依恋的新颖行为干预
  • 批准号:
    10240445
  • 财政年份:
    2017
  • 资助金额:
    $ 9万
  • 项目类别:
Novel Behavioral Intervention to Target Social Reward Sensitivity and Attachment
针对社会奖励敏感性和依恋的新颖行为干预
  • 批准号:
    10596778
  • 财政年份:
    2017
  • 资助金额:
    $ 9万
  • 项目类别:
Novel Behavioral Intervention to Target Social Reward Sensitivity and Attachment
针对社会奖励敏感性和依恋的新颖行为干预
  • 批准号:
    9373740
  • 财政年份:
    2017
  • 资助金额:
    $ 9万
  • 项目类别:
Novel Behavioral Intervention to Target Social Reward Sensitivity and Attachment
针对社会奖励敏感性和依恋的新颖行为干预
  • 批准号:
    10460269
  • 财政年份:
    2017
  • 资助金额:
    $ 9万
  • 项目类别:
Positive Emotional Processing: Exploring Novel Treatment Targets in Social Phobia
积极的情绪处理:探索社交恐惧症的新治疗目标
  • 批准号:
    8208994
  • 财政年份:
    2011
  • 资助金额:
    $ 9万
  • 项目类别:
Positive Emotional Processing: Exploring Novel Treatment Targets in Social Phobia
积极的情绪处理:探索社交恐惧症的新治疗目标
  • 批准号:
    8580673
  • 财政年份:
    2011
  • 资助金额:
    $ 9万
  • 项目类别:
Positive Emotional Processing: Exploring Novel Treatment Targets in Social Phobia
积极的情绪处理:探索社交恐惧症的新治疗目标
  • 批准号:
    8885895
  • 财政年份:
    2011
  • 资助金额:
    $ 9万
  • 项目类别:

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