PENN STATE CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 这是第二次重新提交临床和翻译科学奖的申请。我们描述了宾夕法尼亚州立大学通过宾夕法尼亚州立大学临床和转化科学研究所(CTSI)的工作来转变我们的卫生研究和教育事业的计划。在整个大学里，CTSI的倡议受到了极大的热情和学院和校园的广泛支持，并重申了我们作为一所土地赠与大学的责任。宾夕法尼亚州立大学CTSI的首要目标是成为一个积极参与和积极响应的健康科学研究和教育企业，实现改善健康的承诺。从相关生物、社会和物理科学的独特优势、鼓励跨单位合作的文化和组织结构、从事问题驱动的研究的传统以及与宾夕法尼亚州各地社区的牢固联系入手，我们计划通过以下方式实现这一目标：1)加强社区联盟，以加强信任，增强对差异的认识，并确定需求；2)培养远远超出生物医学传统界限的跨学科合作，以满足这些需求，包括与行业合作；3)共享资源，促进其最熟练的使用；4)利用信息技术中的新工具来收集、共享和挖掘数据，传播新知识；以及5)培养新一代调查人员、卫生专业人员和社区领导人，他们精通各学科，了解伦理原则，对社区的需求敏感，并能够与他人合作应用他们的技能。宾夕法尼亚州立大学在打破障碍和大力支持跨学科合作方面有着丰富的记录，并为CTSI投入了大量资源。在这一修改后的申请中，生物医学信息学领域的一个新的领导团队已被授权扩大基础设施并开发新的软件解决方案，以研究遗传学、表观遗传学和系统生物学。该大学已经增加了对变革性技术、创新教育项目和主要跨学科试点项目的大量健康科学投资。宾夕法尼亚州立大学CTSI将与我们的社区合作伙伴一起，并通过CTSA财团，作为一个协作引擎，推动旨在提高我们服务的人群的健康并更好地预测、预防和治疗疾病的研究计划。RELEVANCE(参见说明)；本提案描述了新成立的宾夕法尼亚州立大学临床和转化科学研究所(CTSI)。我们CTSI倡议的总体目标是振兴我们大学的健康科学研究和教育事业，使其能够更好地实现改善健康的承诺。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. This is the second resubmission application for a Clinical and Translational Science Award. We describe Penn State University's plan to transform our health research and education enterprise through the work of the Penn State Clinical and Translational Science Institute (CTSI). Throughout the University, the CTSI initiative has been greeted with great enthusiasm, broad support across colleges and campuses, and reaffirmation of our responsibility as a land grant University. The overarching goal of the Penn State CTSI is an engaged and responsive health science research and education enterprise that delivers on the promise of improved health. Starting with unique strengths in relevant biological, social and physical sciences, a culture and organizational structure that encourages collaboration across units, a tradition of engaging in problem-driven research, and strong connections to communities throughout Pennsylvania, we plan to achieve this by: 1) bolstering community alliances to strengthen trust, enhance awareness of disparities and ascertain needs; 2) cultivating new problem-driven interdisciplinary collaborations that go well beyond the traditional boundaries of biomedicine to address these needs, including partnering with industry; 3) sharing resources and promoting their most proficient use; 4) capitalizing on novel tools in information technology to collect, share and mine data, anci disseminate new knowledge; and 5) educating a new generation of investigators, health professionals and community leaders who are fluent across disciplines, aware of ethical principles, sensitive to the community's needs, and able to apply their skills in partnership with others. Penn State has a rich track record of breaking down barriers and of strong support for interdisciplinary collaboration, and has committed major resources to the CTSI. In this amended application, a new leadership team in biomedical informatics has been empowered to expand infrastructure and develop new software solutions to study genetics, epigenetics and systems biology. The University has increased its already substantial health science investment in transformational technologies, innovative educational programs, and major interdisciplinary pilot project programs. Jointly with our community partners, and through the CTSA consortium, the Penn State CTSI will serve as a collaborative engine that will drive research initiatives geared to enhance wellness and better predict, preempt and treat disease in the people we serve.RELEVANCE (See instructions); This proposal describes the newly created Penn State Clinical and Translational Science Institute (CTSI). The overarching goal of our CTSI initiative is to revitalize the health science research and education enterprise at our University to better enable it to deliver on the promise of improved health.