Project 1: The Muscle Reflex: Modes of Engagement and Circulatory Consequences

项目 1:肌肉反射:参与模式和循环系统后果

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT – PROJECT 1 Over the last funding period, we demonstrated that the rise in blood pressure (BP) with plantar flexion exercise (PFE) is increased in subjects with peripheral arterial disease (PAD) as compared to healthy subjects. This BP response was due to an accentuated exercise pressor reflex (EPR) seen at low workloads, before subjects developed leg pain. We also demonstrated that the EPR is attenuated by both intravenous ketorolac, a non- steroidal anti-inflammatory drug [NSAID (64)] and high dose intravenous ascorbic acid, an effective short-term antioxidant (62). In healthy subjects, these agents had no effect. Thus, both metabolites of arachidonic acid and oxidative stress contribute to the EPR in PAD. In this renewal, we propose PAD studies examining the consequences of EPR engagement on the circulation to the symptomatic limb and the heart. We have developed new methods, paradigms, and interventions and have collected pilot data demonstrating that our hypotheses are valid and the experiments are feasible. AIM 1: We will examine how the EPR affects blood flow and oxygenation in the exercising leg of PAD patients and healthy subjects. 1A. Are femoral and popliteal blood flow responses to exercise different between PAD and healthy subjects? 1B. Are BOLD SI responses to exercise different between PAD and healthy subjects? 1C. Do pharmacological interventions improve blood flow and oxygenation responses to exercise in PAD? 1D. Does leg revascularization improve leg blood flow and oxygenation responses to exercise? AIM 2: We will examine how the EPR affects blood flow and oxygenation in the resting leg of PAD patients and healthy subjects. 2A. Does the EPR enhance resting leg vasoconstriction in PAD vs. healthy subjects? 2B. Are BOLD SI responses in the resting leg different between PAD and healthy subjects? 2C. Do pharmacological interventions improve resting leg blood flow and oxygenation in PAD? 2D. Does leg revascularization improve resting leg blood flow and oxygenation in PAD? AIM 3: We will examine how the EPR affects coronary blood flow and left ventricular function in PAD patients and healthy subjects. 3A. Is the coronary blood flow response to exercise different between PAD and healthy subjects? 3B. Are left ventricular responses to exercise different between PAD and healthy subjects? 3C. Do pharmacological interventions improve coronary blood flow and left ventricular function in PAD? 3D. Does leg revascularization improve coronary blood flow during exercise in PAD? In summary, Aims 1, 2 and 3 use non-invasive cutting-edge methods to understand the EPR in PAD patients.
项目摘要/摘要-项目1

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Lawrence I Sinoway其他文献

Self-Reported Social Determinants of Health and Area-Level Social Vulnerability
自我报告的健康和地区社会脆弱性的社会决定因素
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    13.8
  • 作者:
    Emily Brignone;Keith LeJeune;Amanda E Mihalko;Amy L Shannon;Lawrence I Sinoway
  • 通讯作者:
    Lawrence I Sinoway

Lawrence I Sinoway的其他文献

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{{ truncateString('Lawrence I Sinoway', 18)}}的其他基金

Core A - Administrative Core
核心 A - 行政核心
  • 批准号:
    10117108
  • 财政年份:
    2017
  • 资助金额:
    $ 78.19万
  • 项目类别:
Penn State Clinical and Translational Science Institute
宾夕法尼亚州立大学临床与转化科学研究所
  • 批准号:
    10387381
  • 财政年份:
    2016
  • 资助金额:
    $ 78.19万
  • 项目类别:
Penn State Clinical and Translational Science Institute
宾夕法尼亚州立大学临床与转化科学研究所
  • 批准号:
    8262017
  • 财政年份:
    2011
  • 资助金额:
    $ 78.19万
  • 项目类别:
Penn State Clinical and Translational Science Institute
宾夕法尼亚州立大学临床与转化科学研究所
  • 批准号:
    8634595
  • 财政年份:
    2011
  • 资助金额:
    $ 78.19万
  • 项目类别:
PENN STATE CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE
宾夕法尼亚州立大学临床与转化科学研究所
  • 批准号:
    8365251
  • 财政年份:
    2011
  • 资助金额:
    $ 78.19万
  • 项目类别:
Penn State Clinical and Translational Science Institute
宾夕法尼亚州立大学临床与转化科学研究所
  • 批准号:
    8490522
  • 财政年份:
    2011
  • 资助金额:
    $ 78.19万
  • 项目类别:
Penn State Clinical and Translational Science Institute
宾夕法尼亚州立大学临床与转化科学研究所
  • 批准号:
    8490521
  • 财政年份:
    2011
  • 资助金额:
    $ 78.19万
  • 项目类别:
Penn State Clinical and Translational Science Institute
宾夕法尼亚州立大学临床与转化科学研究所
  • 批准号:
    8473975
  • 财政年份:
    2011
  • 资助金额:
    $ 78.19万
  • 项目类别:
Penn State Clinical and Translational Science Institute
宾夕法尼亚州立大学临床与转化科学研究所
  • 批准号:
    8270470
  • 财政年份:
    2011
  • 资助金额:
    $ 78.19万
  • 项目类别:
Penn State Clinical and Translational Science Institute
宾夕法尼亚州立大学临床与转化科学研究所
  • 批准号:
    8916921
  • 财政年份:
    2011
  • 资助金额:
    $ 78.19万
  • 项目类别:

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