Penn State Clinical and Translational Science Institute

这是第二次重新提交临床和翻译科学奖的申请。我们描述了 宾夕法尼亚州立大学计划通过以下工作转变我们的健康研究和教育事业 宾夕法尼亚州立大学临床和转化科学研究所(CTSI)。在整个大学，CTSI 倡议得到了大学和校园的极大热情和广泛支持，以及 重申我们作为一所土地赠与大学的责任。宾夕法尼亚州立大学CTSI的首要目标 是一家积极参与和响应的健康科学研究和教育企业，在 改善健康的承诺。从相关的生物、社会和身体方面的独特优势开始 科学，一种鼓励跨单位合作的文化和组织结构，一种 从事以问题为导向的研究，并与宾夕法尼亚州的社区建立强大的联系，我们 计划通过以下方式实现这一目标：1)加强社区联盟以加强信任，提高对 差异和确定需求；2)培养新的以问题为导向的跨学科合作 远远超出生物医学的传统界限来满足这些需求，包括与 行业；3)共享资源并促进其最熟练的使用；4)在 收集、共享和挖掘数据以及传播新知识的信息技术；以及5)教育 新一代调查人员、卫生专业人员和社区领袖 纪律，了解道德原则，对社区的需求敏感，并能够将他们的技能应用于 与他人结成伙伴关系。宾夕法尼亚州立大学在打破障碍和大力支持方面有着丰富的记录 用于跨学科协作，并向CTSI投入了大量资源。在本修订案中 应用程序，生物医学信息学领域的新领导团队已被授权扩大基础设施 并开发新的软件解决方案来研究遗传学、表观遗传学和系统生物学。这所大学有 增加其在变革性技术、创新技术方面本已可观的健康科学投资 教育方案和主要的跨学科试点项目方案。与我们的社区共同努力 合作伙伴，并通过CTSA财团，宾夕法尼亚州立大学CTSI将成为一个协作引擎， 将推动旨在增强健康并更好地预测、抢占和治疗疾病的研究计划 我们所服务的人。

This is the second resubmission application for a Clinical and Translational Science Award. We describe Penn State University's plan to transform our health research and education enterprise through the work of the Penn State Clinical and Translational Science Institute (CTSI). Throughout the University, the CTSI initiative has been greeted with great enthusiasm, broad support across colleges and campuses, and reaffirmation of our responsibility as a land grant University. The overarching goal of the Penn State CTSI is an engaged and responsive health science research and education enterprise that delivers on the promise of improved health. Starting with unique strengths in relevant biological, social and physical sciences, a culture and organizational structure that encourages collaboration across units, a tradition of engaging in problem-driven research, and strong connections to communities throughout Pennsylvania, we plan to achieve this by: 1) bolstering community alliances to strengthen trust, enhance awareness of disparities and ascertain needs; 2) cultivating new problem-driven interdisciplinary collaborations that go well beyond the traditional boundaries of biomedicine to address these needs, including partnering with industry; 3) sharing resources and promoting their most proficient use; 4) capitalizing on novel tools in information technology to collect, share and mine data, and disseminate new knowledge; and 5) educating a new generation of investigators, health professionals and community leaders who are fluent across disciplines, aware of ethical principles, sensitive to the community's needs, and able to apply their skills in partnership with others. Penn State has a rich track record of breaking down barriers and of strong support for interdisciplinary collaboration, and has committed major resources to the CTSI. In this amended application, a new leadership team in biomedical informatics has been empowered to expand infrastructure and develop new software solutions to study genetics, epigenetics and systems biology. The University has increased its already substantial health science investment in transformational technologies, innovative educational programs, and major interdisciplinary pilot project programs. Jointly with our community partners, and through the CTSA consortium, the Penn State CTSI will serve as a collaborative engine that will drive research initiatives geared to enhance wellness and better predict, preempt and treat disease in the people we serve.