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中文摘要
翻译
描述(由申请人提供):拟议研究的广泛目标是了解婴儿期时间视觉处理的发展。在这个建议中进行的实验将结合联合收割机高密度脑电图与现代源成像方法,以评估在婴儿和成人的视觉层次的特定皮层区域的时间响应特性,并将检查神经活动和有意识的视觉感知之间的关系。这种方法将提供第一个图片的功能发展的时间视觉处理的婴儿。视觉运动知觉的缺陷,一个严重依赖于精细时间分辨率的过程,已经在许多发育障碍中报道,包括脆性X综合征和自闭症。从这项研究中获得的信息可以用来提高我们对异常视觉发育的理解,建立非典型时间处理的定量生物标志物,并指导针对改善时间视觉缺陷的干预措施的设计。这项研究与国家眼科研究所的使命非常吻合。 公共卫生相关性:理解时间视觉处理的发展不仅是理解婴儿如何使用视觉信息来理解和执行世界上的动作的必要条件,而且更广泛地说,是理解视觉系统分层皮层区域功能成熟的必要条件。视觉处理的基本机制,包括运动处理,在广泛的发育障碍中受损。了解典型的视觉系统的发展,反过来,阐明赤字的时间处理,可能是特征性的发展人口。这项研究探讨了一个重要的和未回答的领域的视觉研究,从这项研究的结果将是高度相关的使命的国立卫生研究院。
英文摘要
DESCRIPTION (provided by applicant): The broad goal of the proposed research is to understand how temporal visual processing develops during infancy. The experiments conducted in this proposal will combine high-density EEG with modern source- imaging methods to assess temporal response characteristics in specific cortical areas of the visual hierarchy in infants and adults, and will examine the relationship between neural activity and conscious visual perception. This approach will provide the first picture of the functional development of temporal visual processing in infants. Deficits in visual motion perception, a process that is critically dependent on fine temporal resolution, have been reported in a number of developmental disorders, including fragile X syndrome and autism. The information gained from this research can be used to improve our understanding of abnormal visual development, to establish a quantitative biomarker for atypical temporal processing, and to guide the design of interventions targeted at improving temporal visual deficits. This research fits closely with the stated mission of the National Eye Institute. PUBLIC HEALTH RELEVANCE: Understanding the development of temporal visual processing is a requirement for understanding not only how infants use visual information to make sense of and perform actions in the world, but more broadly, the functional maturation of hierarchical cortical areas of the visual system. Basic mechanisms of visual processing, including motion processing, are impaired in a wide range of developmental disorders. Understanding the typically developing visual system will, in turn, shed light on deficits in temporal processing that may be characteristic of atypically developing populations. This study examines an important and unanswered area of vision research, and findings from this study will be highly relevant to the mission of the National Institutes of Health.
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会议论文
Hierarchical development of temporal processing in human visual cortex.
  • 批准号:
    8403628
  • 项目类别:
  • 资助金额:
    $1.56万
  • 财政年份:
    2011
  • 负责人:
    Faraz Farzin
  • 依托单位:
Hierarchical development of temporal processing in human visual cortex.
  • 批准号:
    8216458
  • 项目类别:
  • 资助金额:
    $4.92万
  • 财政年份:
    2011
  • 负责人:
    Faraz Farzin
  • 依托单位:
Spatial and Temporal Visual Attention in Infants with Fragile X Syndrome
Spatial and Temporal Visual Attention in Infants with Fragile X Syndrome
国内基金
海外基金
补阳还五汤通过AGE-RAGE通路调控脓毒症免疫失衡的机制与转化研究
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
  • 批准号:
    JCZRQN202500010
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
  • 依托单位:
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
  • 批准号:
    2025JJ70209
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    雷芬芳
  • 依托单位:
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
  • 批准号:
    --
  • 项目类别:
    面上项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    万荣
  • 依托单位: