Hierarchical development of temporal processing in human visual cortex.

描述（由申请人提供）：拟议研究的总体目标是了解婴儿时期的时间视觉处理是如何发展的。本研究将高密度脑电图与现代源成像方法相结合，评估婴儿和成人视觉层次皮层特定区域的时间反应特征，并研究神经活动与有意识视觉感知之间的关系。这种方法将提供婴儿时间视觉处理功能发展的第一张图片。视觉运动感知缺陷是一个严重依赖于精细时间分辨率的过程，在许多发育障碍中都有报道，包括脆性X综合征和自闭症。从本研究中获得的信息可用于提高我们对视觉发育异常的理解，建立非典型时间加工的定量生物标志物，并指导针对改善时间视觉缺陷的干预设计。这项研究与国家眼科研究所的既定使命密切相关。

DESCRIPTION (provided by applicant): The broad goal of the proposed research is to understand how temporal visual processing develops during infancy. The experiments conducted in this proposal will combine high-density EEG with modern source- imaging methods to assess temporal response characteristics in specific cortical areas of the visual hierarchy in infants and adults, and will examine the relationship between neural activity and conscious visual perception. This approach will provide the first picture of the functional development of temporal visual processing in infants. Deficits in visual motion perception, a process that is critically dependent on fine temporal resolution, have been reported in a number of developmental disorders, including fragile X syndrome and autism. The information gained from this research can be used to improve our understanding of abnormal visual development, to establish a quantitative biomarker for atypical temporal processing, and to guide the design of interventions targeted at improving temporal visual deficits. This research fits closely with the stated mission of the National Eye Institute.