Hierarchical development of temporal processing in human visual cortex.

描述（由申请人提供）：拟议研究的广泛目标是了解婴儿期时间视觉处理的发展。在这个建议中进行的实验将结合联合收割机高密度脑电图与现代源成像方法，以评估在婴儿和成人的视觉层次的特定皮层区域的时间响应特性，并将检查神经活动和有意识的视觉感知之间的关系。这种方法将提供第一个图片的功能发展的时间视觉处理的婴儿。视觉运动知觉的缺陷，一个严重依赖于精细时间分辨率的过程，已经在许多发育障碍中报道，包括脆性X综合征和自闭症。从这项研究中获得的信息可以用来提高我们对异常视觉发育的理解，建立非典型时间处理的定量生物标志物，并指导针对改善时间视觉缺陷的干预措施的设计。这项研究与国家眼科研究所的使命非常吻合。

DESCRIPTION (provided by applicant): The broad goal of the proposed research is to understand how temporal visual processing develops during infancy. The experiments conducted in this proposal will combine high-density EEG with modern source- imaging methods to assess temporal response characteristics in specific cortical areas of the visual hierarchy in infants and adults, and will examine the relationship between neural activity and conscious visual perception. This approach will provide the first picture of the functional development of temporal visual processing in infants. Deficits in visual motion perception, a process that is critically dependent on fine temporal resolution, have been reported in a number of developmental disorders, including fragile X syndrome and autism. The information gained from this research can be used to improve our understanding of abnormal visual development, to establish a quantitative biomarker for atypical temporal processing, and to guide the design of interventions targeted at improving temporal visual deficits. This research fits closely with the stated mission of the National Eye Institute.